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Autism-like syndrome is induced by pharmacological suppression of BET proteins in young mice.
Sullivan JM, Badimon A, Schaefer U, Ayata P, Gray J, Chung CW, von Schimmelmann M, Zhang F, Garton N, Smithers N, Lewis H, Tarakhovsky A, Prinjha RK, Schaefer A. Sullivan JM, et al. Among authors: schaefer a, schaefer u. J Exp Med. 2015 Oct 19;212(11):1771-81. doi: 10.1084/jem.20151271. Epub 2015 Sep 21. J Exp Med. 2015. PMID: 26392221 Free PMC article.
Polycomb repressive complex 2 (PRC2) silences genes responsible for neurodegeneration.
von Schimmelmann M, Feinberg PA, Sullivan JM, Ku SM, Badimon A, Duff MK, Wang Z, Lachmann A, Dewell S, Ma'ayan A, Han MH, Tarakhovsky A, Schaefer A. von Schimmelmann M, et al. Among authors: schaefer a. Nat Neurosci. 2016 Oct;19(10):1321-30. doi: 10.1038/nn.4360. Epub 2016 Aug 15. Nat Neurosci. 2016. PMID: 27526204 Free PMC article.
Epigenetic regulation of brain region-specific microglia clearance activity.
Ayata P, Badimon A, Strasburger HJ, Duff MK, Montgomery SE, Loh YE, Ebert A, Pimenova AA, Ramirez BR, Chan AT, Sullivan JM, Purushothaman I, Scarpa JR, Goate AM, Busslinger M, Shen L, Losic B, Schaefer A. Ayata P, et al. Among authors: schaefer a. Nat Neurosci. 2018 Aug;21(8):1049-1060. doi: 10.1038/s41593-018-0192-3. Epub 2018 Jul 23. Nat Neurosci. 2018. PMID: 30038282 Free PMC article.
Essential role of the histone methyltransferase G9a in cocaine-induced plasticity.
Maze I, Covington HE 3rd, Dietz DM, LaPlant Q, Renthal W, Russo SJ, Mechanic M, Mouzon E, Neve RL, Haggarty SJ, Ren Y, Sampath SC, Hurd YL, Greengard P, Tarakhovsky A, Schaefer A, Nestler EJ. Maze I, et al. Among authors: schaefer a. Science. 2010 Jan 8;327(5962):213-6. doi: 10.1126/science.1179438. Science. 2010. PMID: 20056891 Free PMC article.
An AUTS2-Polycomb complex activates gene expression in the CNS.
Gao Z, Lee P, Stafford JM, von Schimmelmann M, Schaefer A, Reinberg D. Gao Z, et al. Among authors: schaefer a. Nature. 2014 Dec 18;516(7531):349-54. doi: 10.1038/nature13921. Nature. 2014. PMID: 25519132 Free PMC article.
The methyltransferase SETDB1 regulates a large neuron-specific topological chromatin domain.
Jiang Y, Loh YE, Rajarajan P, Hirayama T, Liao W, Kassim BS, Javidfar B, Hartley BJ, Kleofas L, Park RB, Labonte B, Ho SM, Chandrasekaran S, Do C, Ramirez BR, Peter CJ, C W JT, Safaie BM, Morishita H, Roussos P, Nestler EJ, Schaefer A, Tycko B, Brennand KJ, Yagi T, Shen L, Akbarian S. Jiang Y, et al. Among authors: schaefer a. Nat Genet. 2017 Aug;49(8):1239-1250. doi: 10.1038/ng.3906. Epub 2017 Jul 3. Nat Genet. 2017. PMID: 28671686 Free PMC article.
CSF-1 controls cerebellar microglia and is required for motor function and social interaction.
Kana V, Desland FA, Casanova-Acebes M, Ayata P, Badimon A, Nabel E, Yamamuro K, Sneeboer M, Tan IL, Flanigan ME, Rose SA, Chang C, Leader A, Le Bourhis H, Sweet ES, Tung N, Wroblewska A, Lavin Y, See P, Baccarini A, Ginhoux F, Chitu V, Stanley ER, Russo SJ, Yue Z, Brown BD, Joyner AL, De Witte LD, Morishita H, Schaefer A, Merad M. Kana V, et al. Among authors: schaefer a. J Exp Med. 2019 Oct 7;216(10):2265-2281. doi: 10.1084/jem.20182037. Epub 2019 Jul 26. J Exp Med. 2019. PMID: 31350310 Free PMC article.
1,250 results