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Page 1
Identification of a novel orally bioavailable ERK5 inhibitor with selectivity over p38α and BRD4.
Myers SM, Miller DC, Molyneux L, Arasta M, Bawn RH, Blackburn TJ, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hammonds T, Hardcastle IR, Harnor SJ, Heptinstall AB, Lochhead PA, Martin MP, Martin NC, Newell DR, Owen PJ, Pang LC, Reuillon T, Rigoreau LJM, Thomas HD, Tucker JA, Wang LZ, Wong AC, Noble MEM, Wedge SR, Cano C. Myers SM, et al. Among authors: molyneux l. Eur J Med Chem. 2019 Sep 15;178:530-543. doi: 10.1016/j.ejmech.2019.05.057. Epub 2019 May 25. Eur J Med Chem. 2019. PMID: 31212132
High-Throughput Screening and Hit Validation of Extracellular-Related Kinase 5 (ERK5) Inhibitors.
Myers SM, Bawn RH, Bisset LC, Blackburn TJ, Cottyn B, Molyneux L, Wong AC, Cano C, Clegg W, Harrington RW, Leung H, Rigoreau L, Vidot S, Golding BT, Griffin RJ, Hammonds T, Newell DR, Hardcastle IR. Myers SM, et al. Among authors: molyneux l. ACS Comb Sci. 2016 Aug 8;18(8):444-55. doi: 10.1021/acscombsci.5b00155. Epub 2016 Jul 20. ACS Comb Sci. 2016. PMID: 27400250 Free article.
Identification of a novel ligand for the ATAD2 bromodomain with selectivity over BRD4 through a fragment growing approach.
Miller DC, Martin MP, Adhikari S, Brennan A, Endicott JA, Golding BT, Hardcastle IR, Heptinstall A, Hobson S, Jennings C, Molyneux L, Ng Y, Wedge SR, Noble MEM, Cano C. Miller DC, et al. Among authors: molyneux l. Org Biomol Chem. 2018 Mar 14;16(11):1843-1850. doi: 10.1039/c8ob00099a. Org Biomol Chem. 2018. PMID: 29469144 Free PMC article.
Parallel Optimization of Potency and Pharmacokinetics Leading to the Discovery of a Pyrrole Carboxamide ERK5 Kinase Domain Inhibitor.
Miller DC, Reuillon T, Molyneux L, Blackburn T, Cook SJ, Edwards N, Endicott JA, Golding BT, Griffin RJ, Hardcastle I, Harnor SJ, Heptinstall A, Lochhead P, Martin MP, Martin NC, Myers S, Newell DR, Noble RA, Phillips N, Rigoreau L, Thomas H, Tucker JA, Wang LZ, Waring MJ, Wong AC, Wedge SR, Noble MEM, Cano C. Miller DC, et al. Among authors: molyneux l. J Med Chem. 2022 May 12;65(9):6513-6540. doi: 10.1021/acs.jmedchem.1c01756. Epub 2022 Apr 25. J Med Chem. 2022. PMID: 35468293 Free PMC article.
COVID-19 in Malawi: lessons in pandemic preparedness from a tertiary children's hospital.
Chaziya J, Freyne B, Lissauer S, Nielsen M, Langton J, O'Hare B, Molyneux L, Moxon C, Iroh Tam PY, Hoskyns L, Masanjala H, Ilepere S, Ngwira M, Kawaza K, Mumba D, Chimalizeni Y, Dube Q; Department of Paediatrics, Queen Elizabeth Central Hospital. Chaziya J, et al. Among authors: molyneux l. Arch Dis Child. 2021 Mar;106(3):238-240. doi: 10.1136/archdischild-2020-319980. Epub 2020 Dec 23. Arch Dis Child. 2021. PMID: 33361067 Free PMC article. No abstract available.
Nasal CPAP for neonatal respiratory support in low and middle-income countries.
Lissauer T, Duke T, Mellor K, Molyneux L. Lissauer T, et al. Among authors: molyneux l. Arch Dis Child Fetal Neonatal Ed. 2017 May;102(3):F194-F196. doi: 10.1136/archdischild-2016-311653. Epub 2017 Feb 20. Arch Dis Child Fetal Neonatal Ed. 2017. PMID: 28219880 No abstract available.
A step at a time.
Molyneux L. Molyneux L. Epilepsy Behav. 2017 Feb;67:130-132. doi: 10.1016/j.yebeh.2016.08.016. Epub 2016 Nov 4. Epilepsy Behav. 2017. PMID: 27825562 No abstract available.
Born too soon: care for the preterm baby.
Lawn JE, Davidge R, Paul VK, von Xylander S, de Graft Johnson J, Costello A, Kinney MV, Segre J, Molyneux L. Lawn JE, et al. Among authors: molyneux l. Reprod Health. 2013;10 Suppl 1(Suppl 1):S5. doi: 10.1186/1742-4755-10-S1-S5. Epub 2013 Nov 15. Reprod Health. 2013. PMID: 24625233 Free PMC article. Review.
β-adrenergic sweat secretion as a diagnostic test for cystic fibrosis.
Quinton P, Molyneux L, Ip W, Dupuis A, Avolio J, Tullis E, Conrad D, Shamsuddin AK, Durie P, Gonska T. Quinton P, et al. Among authors: molyneux l. Am J Respir Crit Care Med. 2012 Oct 15;186(8):732-9. doi: 10.1164/rccm.201205-0922OC. Epub 2012 Aug 2. Am J Respir Crit Care Med. 2012. PMID: 22859523
27 results