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Genetic variation in GNB5 causes bradycardia by augmenting the cholinergic response via increased acetylcholine-activated potassium current (IK,ACh).
Veerman CC, Mengarelli I, Koopman CD, Wilders R, van Amersfoorth SC, Bakker D, Wolswinkel R, Hababa M, de Boer TP, Guan K, Milnes J, Lodder EM, Bakkers J, Verkerk AO, Bezzina CR. Veerman CC, et al. Among authors: de boer tp. Dis Model Mech. 2019 Jul 9;12(7):dmm037994. doi: 10.1242/dmm.037994. Dis Model Mech. 2019. PMID: 31208990 Free PMC article.
Drug-induced torsade de pointes arrhythmias in the chronic AV block dog are perpetuated by focal activity.
Boulaksil M, Jungschleger JG, Antoons G, Houtman MJ, de Boer TP, Wilders R, Beekman JD, Maessen JG, van der Hulst FF, van der Heyden MA, van Veen TA, van Rijen HV, de Bakker JM, Vos MA. Boulaksil M, et al. Among authors: de boer tp, de bakker jm. Circ Arrhythm Electrophysiol. 2011 Aug;4(4):566-76. doi: 10.1161/CIRCEP.110.958991. Epub 2011 May 27. Circ Arrhythm Electrophysiol. 2011. PMID: 21622813
GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.
Lodder EM, De Nittis P, Koopman CD, Wiszniewski W, Moura de Souza CF, Lahrouchi N, Guex N, Napolioni V, Tessadori F, Beekman L, Nannenberg EA, Boualla L, Blom NA, de Graaff W, Kamermans M, Cocciadiferro D, Malerba N, Mandriani B, Akdemir ZHC, Fish RJ, Eldomery MK, Ratbi I, Wilde AAM, de Boer T, Simonds WF, Neerman-Arbez M, Sutton VR, Kok F, Lupski JR, Reymond A, Bezzina CR, Bakkers J, Merla G. Lodder EM, et al. Am J Hum Genet. 2016 Sep 1;99(3):704-710. doi: 10.1016/j.ajhg.2016.06.025. Epub 2016 Aug 11. Am J Hum Genet. 2016. PMID: 27523599 Free PMC article.
GNB5 Mutations Cause an Autosomal-Recessive Multisystem Syndrome with Sinus Bradycardia and Cognitive Disability.
Lodder EM, De Nittis P, Koopman CD, Wiszniewski W, Moura de Souza CF, Lahrouchi N, Guex N, Napolioni V, Tessadori F, Beekman L, Nannenberg EA, Boualla L, Blom NA, de Graaff W, Kamermans M, Cocciadiferro D, Malerba N, Mandriani B, Coban Akdemir ZH, Fish RJ, Eldomery MK, Ratbi I, Wilde AAM, de Boer T, Simonds WF, Neerman-Arbez M, Sutton VR, Kok F, Lupski JR, Reymond A, Bezzina CR, Bakkers J, Merla G. Lodder EM, et al. Am J Hum Genet. 2016 Sep 1;99(3):786. doi: 10.1016/j.ajhg.2016.08.011. Epub 2016 Sep 1. Am J Hum Genet. 2016. PMID: 27588455 Free PMC article. No abstract available.
Cardiac optogenetics: using light to monitor cardiac physiology.
Koopman CD, Zimmermann WH, Knöpfel T, de Boer TP. Koopman CD, et al. Among authors: de boer tp. Basic Res Cardiol. 2017 Aug 31;112(5):56. doi: 10.1007/s00395-017-0645-y. Basic Res Cardiol. 2017. PMID: 28861604 Free PMC article. Review.
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