Chen L - Search Results

1

Discovery of Ziresovir as a Potent, Selective, and Orally Bioavailable Respiratory Syncytial Virus Fusion Protein Inhibitor.

Zheng X, Gao L, Wang L, Liang C, Wang B, Liu Y, Feng S, Zhang B, Zhou M, Yu X, Xiang K, Chen L, Guo T, Shen HC, Zou G, Wu JZ, Yun H. Zheng X, et al. Among authors: chen l. J Med Chem. 2019 Jul 11;62(13):6003-6014. doi: 10.1021/acs.jmedchem.9b00654. Epub 2019 Jun 26. J Med Chem. 2019. PMID: 31194544

2

Discovery of Benzoazepinequinoline (BAQ) Derivatives as Novel, Potent, Orally Bioavailable Respiratory Syncytial Virus Fusion Inhibitors.

Zheng X, Liang C, Wang L, Wang B, Liu Y, Feng S, Wu JZ, Gao L, Feng L, Chen L, Guo T, Shen HC, Yun H. Zheng X, et al. Among authors: chen l. J Med Chem. 2018 Nov 21;61(22):10228-10241. doi: 10.1021/acs.jmedchem.8b01394. Epub 2018 Nov 2. J Med Chem. 2018. PMID: 30339388

3

Discovery of novel 1-phenyl-cycloalkane carbamides as potent and selective influenza fusion inhibitors.

Tang G, Qiu Z, Lin X, Li W, Zhu L, Li S, Li H, Wang L, Chen L, Wu JZ, Yang W. Tang G, et al. Among authors: chen l. Bioorg Med Chem Lett. 2010 Jun 15;20(12):3507-10. doi: 10.1016/j.bmcl.2010.04.141. Epub 2010 May 5. Bioorg Med Chem Lett. 2010. PMID: 20494579

4

Pharmacokinetic optimization of class-selective histone deacetylase inhibitors and identification of associated candidate predictive biomarkers of hepatocellular carcinoma tumor response.

Wong JC, Tang G, Wu X, Liang C, Zhang Z, Guo L, Peng Z, Zhang W, Lin X, Wang Z, Mei J, Chen J, Pan S, Zhang N, Liu Y, Zhou M, Feng L, Zhao W, Li S, Zhang C, Zhang M, Rong Y, Jin TG, Zhang X, Ren S, Ji Y, Zhao R, She J, Ren Y, Xu C, Chen D, Cai J, Shan S, Pan D, Ning Z, Lu X, Chen T, He Y, Chen L. Wong JC, et al. Among authors: chen j, chen l, chen d, chen t. J Med Chem. 2012 Oct 25;55(20):8903-25. doi: 10.1021/jm3011838. Epub 2012 Oct 12. J Med Chem. 2012. PMID: 23061376

5

Design and synthesis of benzenesulfonamide derivatives as potent anti-influenza hemagglutinin inhibitors.

Tang G, Lin X, Qiu Z, Li W, Zhu L, Wang L, Li S, Li H, Lin W, Yang M, Guo T, Chen L, Lee D, Wu JZ, Yang W. Tang G, et al. Among authors: chen l. ACS Med Chem Lett. 2011 Jun 7;2(8):603-7. doi: 10.1021/ml2000627. eCollection 2011 Aug 11. ACS Med Chem Lett. 2011. PMID: 24900355 Free PMC article.

6

Identification of a novel aminotetralin class of HDAC6 and HDAC8 selective inhibitors.

Tang G, Wong JC, Zhang W, Wang Z, Zhang N, Peng Z, Zhang Z, Rong Y, Li S, Zhang M, Yu L, Feng T, Zhang X, Wu X, Wu JZ, Chen L. Tang G, et al. Among authors: chen l. J Med Chem. 2014 Oct 9;57(19):8026-34. doi: 10.1021/jm5008962. Epub 2014 Sep 30. J Med Chem. 2014. PMID: 25238284

7

Inhibition of influenza A virus (H1N1) fusion by benzenesulfonamide derivatives targeting viral hemagglutinin.

Zhu L, Li Y, Li S, Li H, Qiu Z, Lee C, Lu H, Lin X, Zhao R, Chen L, Wu JZ, Tang G, Yang W. Zhu L, et al. Among authors: chen l. PLoS One. 2011;6(12):e29120. doi: 10.1371/journal.pone.0029120. Epub 2011 Dec 15. PLoS One. 2011. PMID: 22195002 Free PMC article.

8

Small molecule R1498 as a well-tolerated and orally active kinase inhibitor for hepatocellular carcinoma and gastric cancer treatment via targeting angiogenesis and mitosis pathways.

Zhang C, Wu X, Zhang M, Zhu L, Zhao R, Xu D, Lin Z, Liang C, Chen T, Chen L, Ren Y, Zhang J, Qin N, Zhang X. Zhang C, et al. Among authors: chen l, chen t. PLoS One. 2013 Jun 5;8(6):e65264. doi: 10.1371/journal.pone.0065264. Print 2013. PLoS One. 2013. PMID: 23755206 Free PMC article.

9

Identification of an N-oxide pyridine GW4064 analog as a potent FXR agonist.

Feng S, Yang M, Zhang Z, Wang Z, Hong D, Richter H, Benson GM, Bleicher K, Grether U, Martin RE, Plancher JM, Kuhn B, Rudolph MG, Chen L. Feng S, et al. Among authors: chen l. Bioorg Med Chem Lett. 2009 May 1;19(9):2595-8. doi: 10.1016/j.bmcl.2009.03.008. Epub 2009 Mar 9. Bioorg Med Chem Lett. 2009. PMID: 19328688

10

Synthesis and evaluation of pyrido-thieno-pyrimidines as potent and selective Cdc7 kinase inhibitors.

Zhao C, Tovar C, Yin X, Xu Q, Todorov IT, Vassilev LT, Chen L. Zhao C, et al. Among authors: chen l. Bioorg Med Chem Lett. 2009 Jan 15;19(2):319-23. doi: 10.1016/j.bmcl.2008.11.093. Epub 2008 Nov 27. Bioorg Med Chem Lett. 2009. PMID: 19071019

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