Vasukuttan V - Search Results

1

Functionalized 6-(Piperidin-1-yl)-8,9-Diphenyl Purines as Peripherally Restricted Inverse Agonists of the CB1 Receptor.

Amato G, Manke A, Wiethe R, Vasukuttan V, Snyder R, Yueh YL, Decker A, Runyon S, Maitra R. Amato G, et al. Among authors: vasukuttan v. J Med Chem. 2019 Jul 11;62(13):6330-6345. doi: 10.1021/acs.jmedchem.9b00727. Epub 2019 Jun 22. J Med Chem. 2019. PMID: 31185168 Free PMC article.

2

Discovery of a novel small molecule agonist scaffold for the APJ receptor.

Narayanan S, Maitra R, Deschamps JR, Bortoff K, Thomas JB, Zhang Y, Warner K, Vasukuttan V, Decker A, Runyon SP. Narayanan S, et al. Among authors: vasukuttan v. Bioorg Med Chem. 2016 Aug 15;24(16):3758-70. doi: 10.1016/j.bmc.2016.06.018. Epub 2016 Jun 11. Bioorg Med Chem. 2016. PMID: 27369451 Free PMC article.

3

Blocking Alcoholic Steatosis in Mice with a Peripherally Restricted Purine Antagonist of the Type 1 Cannabinoid Receptor.

Amato GS, Manke A, Harris DL, Wiethe RW, Vasukuttan V, Snyder RW, Lefever TW, Cortes R, Zhang Y, Wang S, Runyon SP, Maitra R. Amato GS, et al. Among authors: vasukuttan v. J Med Chem. 2018 May 24;61(10):4370-4385. doi: 10.1021/acs.jmedchem.7b01820. Epub 2018 May 10. J Med Chem. 2018. PMID: 29688015 Free PMC article.

4

Synthesis and pharmacological characterization of functionalized 6-piperazin-1-yl-purines as cannabinoid receptor 1 (CB1) inverse agonists.

Amato GS, Manke A, Vasukuttan V, Wiethe RW, Snyder RW, Runyon SP, Maitra R. Amato GS, et al. Among authors: vasukuttan v. Bioorg Med Chem. 2018 Aug 15;26(15):4518-4531. doi: 10.1016/j.bmc.2018.07.043. Epub 2018 Jul 27. Bioorg Med Chem. 2018. PMID: 30077609 Free PMC article.

5

Functionalized 6-(piperidin-1-yl)-8,9-diphenyl purines as inverse agonists of the CB1 receptor - SAR efforts towards selectivity and peripheralization.

Amato G, Wiethe R, Manke A, Vasukuttan V, Snyder R, Runyon S, Maitra R. Amato G, et al. Among authors: vasukuttan v. Bioorg Med Chem. 2019 Aug 15;27(16):3632-3649. doi: 10.1016/j.bmc.2019.07.002. Epub 2019 Jul 4. Bioorg Med Chem. 2019. PMID: 31301950 Free PMC article.

6

Identification of potent pyrazole based APELIN receptor (APJ) agonists.

Narayanan S, Vasukuttan V, Rajagopal S, Maitra R, Runyon SP. Narayanan S, et al. Among authors: vasukuttan v. Bioorg Med Chem. 2020 Feb 15;28(4):115237. doi: 10.1016/j.bmc.2019.115237. Epub 2019 Nov 30. Bioorg Med Chem. 2020. PMID: 31948845 Free PMC article.

7

Pyrazole Agonist of the Apelin Receptor Improves Symptoms of Metabolic Syndrome in Mice.

Narayanan S, Wang S, Vasukuttan V, Vyas Devambatla RK, Dai D, Jin C, Snyder R, Laudermilk L, Runyon SP, Maitra R. Narayanan S, et al. Among authors: vasukuttan v. J Med Chem. 2021 Mar 25;64(6):3006-3025. doi: 10.1021/acs.jmedchem.0c01448. Epub 2021 Mar 11. J Med Chem. 2021. PMID: 33705126

8

Indole-Containing Amidinohydrazones as Nonpeptide, Dual RXFP3/4 Agonists: Synthesis, Structure-Activity Relationship, and Molecular Modeling Studies.

Guan D, Rahman MT, Gay EA, Vasukuttan V, Mathews KM, Decker AM, Williams AH, Zhan CG, Jin C. Guan D, et al. Among authors: vasukuttan v. J Med Chem. 2021 Dec 23;64(24):17866-17886. doi: 10.1021/acs.jmedchem.1c01081. Epub 2021 Dec 2. J Med Chem. 2021. PMID: 34855388 Free PMC article.

9

Discovery and Characterization of the First Nonpeptide Antagonists for the Relaxin-3/RXFP3 System.

Gay EA, Guan D, Van Voorhies K, Vasukuttan V, Mathews KM, Besheer J, Jin C. Gay EA, et al. Among authors: vasukuttan v. J Med Chem. 2022 Jun 9;65(11):7959-7974. doi: 10.1021/acs.jmedchem.2c00508. Epub 2022 May 20. J Med Chem. 2022. PMID: 35594150 Free PMC article.

10

Synthesis and characterization of an orally bioavailable small molecule agonist of the apelin receptor.

Narayanan S, Dai D, Vyas Devambatla RK, Albert V, Bruneau-Latour N, Vasukuttan V, Ciblat S, Rehder K, Runyon SP, Maitra R. Narayanan S, et al. Among authors: vasukuttan v. Bioorg Med Chem. 2022 Jul 15;66:116789. doi: 10.1016/j.bmc.2022.116789. Epub 2022 May 6. Bioorg Med Chem. 2022. PMID: 35594649

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