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Drivers of AR indifferent anti-androgen resistance in prostate cancer cells.
Handle F, Prekovic S, Helsen C, Van den Broeck T, Smeets E, Moris L, Eerlings R, Kharraz SE, Urbanucci A, Mills IG, Joniau S, Attard G, Claessens F. Handle F, et al. Sci Rep. 2019 Sep 24;9(1):13786. doi: 10.1038/s41598-019-50220-1. Sci Rep. 2019. PMID: 31551480 Free PMC article.
Molecular underpinnings of enzalutamide resistance.
Prekovic S, van den Broeck T, Linder S, van Royen ME, Houtsmuller AB, Handle F, Joniau S, Zwart W, Claessens F. Prekovic S, et al. Among authors: handle f. Endocr Relat Cancer. 2018 Nov 1;25(11):R545–R557. doi: 10.1530/ERC-17-0136. Endocr Relat Cancer. 2018. PMID: 30306781
Single-cell ATAC and RNA sequencing reveal pre-existing and persistent cells associated with prostate cancer relapse.
Taavitsainen S, Engedal N, Cao S, Handle F, Erickson A, Prekovic S, Wetterskog D, Tolonen T, Vuorinen EM, Kiviaho A, Nätkin R, Häkkinen T, Devlies W, Henttinen S, Kaarijärvi R, Lahnalampi M, Kaljunen H, Nowakowska K, Syvälä H, Bläuer M, Cremaschi P, Claessens F, Visakorpi T, Tammela TLJ, Murtola T, Granberg KJ, Lamb AD, Ketola K, Mills IG, Attard G, Wang W, Nykter M, Urbanucci A. Taavitsainen S, et al. Among authors: handle f. Nat Commun. 2021 Sep 6;12(1):5307. doi: 10.1038/s41467-021-25624-1. Nat Commun. 2021. PMID: 34489465 Free PMC article.
The androgen receptor depends on ligand-binding domain dimerization for transcriptional activation.
El Kharraz S, Dubois V, van Royen ME, Houtsmuller AB, Pavlova E, Atanassova N, Nguyen T, Voet A, Eerlings R, Handle F, Prekovic S, Smeets E, Moris L, Devlies W, Ohlsson C, Poutanen M, Verstrepen KJ, Carmeliet G, Launonen KM, Helminen L, Palvimo JJ, Libert C, Vanderschueren D, Helsen C, Claessens F. El Kharraz S, et al. Among authors: handle f. EMBO Rep. 2021 Dec 6;22(12):e52764. doi: 10.15252/embr.202152764. Epub 2021 Oct 18. EMBO Rep. 2021. PMID: 34661369 Free PMC article.
Antizyme Inhibitor 1 Regulates Matrikine Expression and Enhances the Metastatic Potential of Aggressive Primary Prostate Cancer.
Van den Broeck T, Moris L, Gevaert T, Davicioni E, Boeckx B, Lambrechts D, Helsen C, Handle F, Ghesquière B, Soenen S, Smeets E, Eerlings R, El Kharraz S, Devlies W, Karnes RJ, Lotan T, Van Poppel H, Joniau S, Claessens F. Van den Broeck T, et al. Among authors: handle f. Mol Cancer Res. 2022 Apr 1;20(4):527-541. doi: 10.1158/1541-7786.MCR-21-0388. Mol Cancer Res. 2022. PMID: 35082164
A disease-associated missense mutation in CYP4F3 affects the metabolism of leukotriene B4 via disruption of electron transfer.
Smeets E, Huang S, Lee XY, Van Nieuwenhove E, Helsen C, Handle F, Moris L, El Kharraz S, Eerlings R, Devlies W, Willemsen M, Bücken L, Prezzemolo T, Humblet-Baron S, Voet A, Rochtus A, Van Schepdael A, de Zegher F, Claessens F. Smeets E, et al. Among authors: handle f. J Cachexia Sarcopenia Muscle. 2022 Aug;13(4):2242-2253. doi: 10.1002/jcsm.13022. Epub 2022 Jun 9. J Cachexia Sarcopenia Muscle. 2022. PMID: 35686338 Free PMC article.
31 results