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Crystal structure of F95Q epi-isozizaene synthase, an engineered sesquiterpene cyclase that generates biofuel precursors β- and γ-curcumene.
J Struct Biol. 2019 Aug 1;207(2):218-224. doi: 10.1016/j.jsb.2019.05.011. Epub 2019 May 29.
J Struct Biol. 2019.
PMID: 31152775
Free PMC article.
Structural studies of geranylgeranylglyceryl phosphate synthase, a prenyltransferase found in thermophilic Euryarchaeota.
Blank PN, Barnett AA, Ronnebaum TA, Alderfer KE, Gillott BN, Christianson DW, Himmelberger JA.
Blank PN, et al.
Acta Crystallogr D Struct Biol. 2020 Jun 1;76(Pt 6):542-557. doi: 10.1107/S2059798320004878. Epub 2020 May 29.
Acta Crystallogr D Struct Biol. 2020.
PMID: 32496216
Free PMC article.
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Substitution of Aromatic Residues with Polar Residues in the Active Site Pocket of epi-Isozizaene Synthase Leads to the Generation of New Cyclic Sesquiterpenes.
Blank PN, Barrow GH, Chou WKW, Duan L, Cane DE, Christianson DW.
Blank PN, et al.
Biochemistry. 2017 Oct 31;56(43):5798-5811. doi: 10.1021/acs.biochem.7b00895. Epub 2017 Oct 17.
Biochemistry. 2017.
PMID: 28967743
Free PMC article.
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Crystal Structure of Cucumene Synthase, a Terpenoid Cyclase That Generates a Linear Triquinane Sesquiterpene.
Blank PN, Pemberton TA, Chow JY, Poulter CD, Christianson DW.
Blank PN, et al.
Biochemistry. 2018 Nov 6;57(44):6326-6335. doi: 10.1021/acs.biochem.8b00899. Epub 2018 Oct 22.
Biochemistry. 2018.
PMID: 30346736
Free PMC article.
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Structure of Sesquisabinene Synthase 1, a Terpenoid Cyclase That Generates a Strained [3.1.0] Bridged-Bicyclic Product.
Blank PN, Shinsky SA, Christianson DW.
Blank PN, et al.
ACS Chem Biol. 2019 May 17;14(5):1011-1019. doi: 10.1021/acschembio.9b00218. Epub 2019 Apr 17.
ACS Chem Biol. 2019.
PMID: 30977996
Free PMC article.
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