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The Pro-Oncogenic Adaptor CIN85 Acts as an Inhibitory Binding Partner of Hypoxia-Inducible Factor Prolyl Hydroxylase 2.
Kozlova N, Mennerich D, Samoylenko A, Dimova EY, Koivunen P, Biterova E, Richter K, Hassinen A, Kellokumpu S, Manninen A, Miinalainen I, Glumoff V, Ruddock L, Drobot LB, Kietzmann T. Kozlova N, et al. Among authors: ruddock l. Cancer Res. 2019 Aug 15;79(16):4042-4056. doi: 10.1158/0008-5472.CAN-18-3852. Epub 2019 May 29. Cancer Res. 2019. PMID: 31142511
Domains b' and a' of protein disulfide isomerase fulfill the minimum requirement for function as a subunit of prolyl 4-hydroxylase. The N-terminal domains a and b enhances this function and can be substituted in part by those of ERp57.
Pirneskoski A, Ruddock LW, Klappa P, Freedman RB, Kivirikko KI, Koivunen P. Pirneskoski A, et al. Among authors: ruddock lw. J Biol Chem. 2001 Apr 6;276(14):11287-93. doi: 10.1074/jbc.M010656200. Epub 2000 Dec 29. J Biol Chem. 2001. PMID: 11134056 Free article.
NHLRC2 variants identified in patients with fibrosis, neurodegeneration, and cerebral angiomatosis (FINCA): characterisation of a novel cerebropulmonary disease.
Uusimaa J, Kaarteenaho R, Paakkola T, Tuominen H, Karjalainen MK, Nadaf J, Varilo T, Uusi-Mäkelä M, Suo-Palosaari M, Pietilä I, Hiltunen AE, Ruddock L, Alanen H, Biterova E, Miinalainen I, Salminen A, Soininen R, Manninen A, Sormunen R, Kaakinen M, Vuolteenaho R, Herva R, Vieira P, Dunder T, Kokkonen H, Moilanen JS, Rantala H, Nogee LM, Majewski J, Rämet M, Hallman M, Hinttala R. Uusimaa J, et al. Among authors: ruddock l. Acta Neuropathol. 2018 May;135(5):727-742. doi: 10.1007/s00401-018-1817-z. Epub 2018 Feb 8. Acta Neuropathol. 2018. PMID: 29423877
Crystal structure of human anterior gradient protein 3.
Nguyen VD, Biterova E, Salin M, Wierenga RK, Ruddock LW. Nguyen VD, et al. Acta Crystallogr F Struct Biol Commun. 2018 Jul 1;74(Pt 7):425-430. doi: 10.1107/S2053230X18009093. Epub 2018 Jun 26. Acta Crystallogr F Struct Biol Commun. 2018. PMID: 29969106 Free PMC article.
112 results