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Targeting the Interplay between Epithelial-to-Mesenchymal-Transition and the Immune System for Effective Immunotherapy.
Soundararajan R, Fradette JJ, Konen JM, Moulder S, Zhang X, Gibbons DL, Varadarajan N, Wistuba II, Tripathy D, Bernatchez C, Byers LA, Chang JT, Contreras A, Lim B, Parra ER, Roarty EB, Wang J, Yang F, Barton M, Rosen JM, Mani SA. Soundararajan R, et al. Among authors: varadarajan n. Cancers (Basel). 2019 May 24;11(5):714. doi: 10.3390/cancers11050714. Cancers (Basel). 2019. PMID: 31137625 Free PMC article. Review.
Multifaceted Role of BTLA in the Control of CD8+ T-cell Fate after Antigen Encounter.
Ritthipichai K, Haymaker CL, Martinez M, Aschenbrenner A, Yi X, Zhang M, Kale C, Vence LM, Roszik J, Hailemichael Y, Overwijk WW, Varadarajan N, Nurieva R, Radvanyi LG, Hwu P, Bernatchez C. Ritthipichai K, et al. Among authors: varadarajan n. Clin Cancer Res. 2017 Oct 15;23(20):6151-6164. doi: 10.1158/1078-0432.CCR-16-1217. Epub 2017 Jul 28. Clin Cancer Res. 2017. PMID: 28754817 Free PMC article.
Mesoscopic protein-rich clusters host the nucleation of mutant p53 amyloid fibrils.
Yang DS, Saeedi A, Davtyan A, Fathi M, Sherman MB, Safari MS, Klindziuk A, Barton MC, Varadarajan N, Kolomeisky AB, Vekilov PG. Yang DS, et al. Among authors: varadarajan n. Proc Natl Acad Sci U S A. 2021 Mar 9;118(10):e2015618118. doi: 10.1073/pnas.2015618118. Proc Natl Acad Sci U S A. 2021. PMID: 33653952 Free PMC article.
CD8+ T cells inhibit metastasis and CXCL4 regulates its function.
Joseph R, Soundararajan R, Vasaikar S, Yang F, Allton KL, Tian L, den Hollander P, Isgandarova S, Haemmerle M, Mino B, Zhou T, Shin C, Martinez-Paniagua M, Sahin AA, Rodriguez-Canales J, Gelovani J, Chang JT, Acharya G, Sood AK, Wistuba II, Gibbons DL, Solis LM, Barton MC, Varadarajan N, Rosen JM, Zhang XH, Mani SA. Joseph R, et al. Among authors: varadarajan n. Br J Cancer. 2021 Jul;125(2):176-189. doi: 10.1038/s41416-021-01338-5. Epub 2021 Apr 1. Br J Cancer. 2021. PMID: 33795809 Free PMC article.
Targeting a cytokine checkpoint enhances the fitness of armored cord blood CAR-NK cells.
Daher M, Basar R, Gokdemir E, Baran N, Uprety N, Nunez Cortes AK, Mendt M, Kerbauy LN, Banerjee PP, Shanley M, Imahashi N, Li L, Lim FLWI, Fathi M, Rezvan A, Mohanty V, Shen Y, Shaim H, Lu J, Ozcan G, Ensley E, Kaplan M, Nandivada V, Bdiwi M, Acharya S, Xi Y, Wan X, Mak D, Liu E, Jiang XR, Ang S, Muniz-Feliciano L, Li Y, Wang J, Kordasti S, Petrov N, Varadarajan N, Marin D, Brunetti L, Skinner RJ, Lyu S, Silva L, Turk R, Schubert MS, Rettig GR, McNeill MS, Kurgan G, Behlke MA, Li H, Fowlkes NW, Chen K, Konopleva M, Champlin RE, Shpall EJ, Rezvani K. Daher M, et al. Among authors: varadarajan n. Blood. 2021 Feb 4;137(5):624-636. doi: 10.1182/blood.2020007748. Blood. 2021. PMID: 32902645 Free PMC article.
Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling.
Rezvan A, Romain G, Fathi M, Heeke D, Martinez-Paniagua M, An X, Bandey IN, Montalvo MJ, Adolacion JRT, Saeedi A, Sadeghi F, Fousek K, Puebla-Osorio N, Cooper LJN, Bernatchez C, Singh H, Ahmed N, Mattie M, Bot A, Neelapu S, Varadarajan N. Rezvan A, et al. Among authors: varadarajan n. Nat Cancer. 2024 May 15. doi: 10.1038/s43018-024-00768-3. Online ahead of print. Nat Cancer. 2024. PMID: 38750245
Author Correction: Identification of a clinically efficacious CAR T cell subset in diffuse large B cell lymphoma by dynamic multidimensional single-cell profiling.
Rezvan A, Romain G, Fathi M, Heeke D, Martinez-Paniagua M, An X, Bandey IN, Montalvo MJ, Adolacion JRT, Saeedi A, Sadeghi F, Fousek K, Puebla-Osorio N, Cooper LJN, Bernatchez C, Singh H, Ahmed N, Mattie M, Bot A, Neelapu S, Varadarajan N. Rezvan A, et al. Among authors: varadarajan n. Nat Cancer. 2024 May 22. doi: 10.1038/s43018-024-00786-1. Online ahead of print. Nat Cancer. 2024. PMID: 38778179 No abstract available.
Integrating genome-wide CRISPR immune screen with multi-omic clinical data reveals distinct classes of tumor intrinsic immune regulators.
Hou J, Wang Y, Shi L, Chen Y, Xu C, Saeedi A, Pan K, Bohat R, Egan NA, McKenzie JA, Mbofung RM, Williams LJ, Yang Z, Sun M, Liang X, Rodon Ahnert J, Varadarajan N, Yee C, Chen Y, Hwu P, Peng W. Hou J, et al. Among authors: varadarajan n. J Immunother Cancer. 2021 Feb;9(2):e001819. doi: 10.1136/jitc-2020-001819. J Immunother Cancer. 2021. PMID: 33589527 Free PMC article.
77 results