Santagata S - Search Results

1

Mitochondrial metabolism promotes adaptation to proteotoxic stress.

Tsvetkov P, Detappe A, Cai K, Keys HR, Brune Z, Ying W, Thiru P, Reidy M, Kugener G, Rossen J, Kocak M, Kory N, Tsherniak A, Santagata S, Whitesell L, Ghobrial IM, Markley JL, Lindquist S, Golub TR. Tsvetkov P, et al. Among authors: santagata s. Nat Chem Biol. 2019 Jul;15(7):681-689. doi: 10.1038/s41589-019-0291-9. Epub 2019 May 27. Nat Chem Biol. 2019. PMID: 31133756 Free PMC article.

2

Rapid selection of cyclic peptides that reduce alpha-synuclein toxicity in yeast and animal models.

Kritzer JA, Hamamichi S, McCaffery JM, Santagata S, Naumann TA, Caldwell KA, Caldwell GA, Lindquist S. Kritzer JA, et al. Among authors: santagata s. Nat Chem Biol. 2009 Sep;5(9):655-63. doi: 10.1038/nchembio.193. Epub 2009 Jul 13. Nat Chem Biol. 2009. PMID: 19597508 Free PMC article.

3

High levels of nuclear heat-shock factor 1 (HSF1) are associated with poor prognosis in breast cancer.

Santagata S, Hu R, Lin NU, Mendillo ML, Collins LC, Hankinson SE, Schnitt SJ, Whitesell L, Tamimi RM, Lindquist S, Ince TA. Santagata S, et al. Proc Natl Acad Sci U S A. 2011 Nov 8;108(45):18378-83. doi: 10.1073/pnas.1115031108. Epub 2011 Oct 31. Proc Natl Acad Sci U S A. 2011. PMID: 22042860 Free PMC article.

4

Using the heat-shock response to discover anticancer compounds that target protein homeostasis.

Santagata S, Xu YM, Wijeratne EM, Kontnik R, Rooney C, Perley CC, Kwon H, Clardy J, Kesari S, Whitesell L, Lindquist S, Gunatilaka AA. Santagata S, et al. ACS Chem Biol. 2012 Feb 17;7(2):340-9. doi: 10.1021/cb200353m. Epub 2011 Nov 30. ACS Chem Biol. 2012. PMID: 22050377 Free PMC article.

5

Inhibiting HSP90 to treat cancer: a strategy in evolution.

Whitesell L, Santagata S, Lin NU. Whitesell L, et al. Among authors: santagata s. Curr Mol Med. 2012 Nov 1;12(9):1108-24. doi: 10.2174/156652412803306657. Curr Mol Med. 2012. PMID: 22804235 Review.

6

HSF1 drives a transcriptional program distinct from heat shock to support highly malignant human cancers.

Mendillo ML, Santagata S, Koeva M, Bell GW, Hu R, Tamimi RM, Fraenkel E, Ince TA, Whitesell L, Lindquist S. Mendillo ML, et al. Among authors: santagata s. Cell. 2012 Aug 3;150(3):549-62. doi: 10.1016/j.cell.2012.06.031. Cell. 2012. PMID: 22863008 Free PMC article.

7

Loss of tumor suppressor NF1 activates HSF1 to promote carcinogenesis.

Dai C, Santagata S, Tang Z, Shi J, Cao J, Kwon H, Bronson RT, Whitesell L, Lindquist S. Dai C, et al. Among authors: santagata s. J Clin Invest. 2012 Oct;122(10):3742-54. doi: 10.1172/JCI62727. Epub 2012 Sep 4. J Clin Invest. 2012. PMID: 22945628 Free PMC article.

8

Chaperones as thermodynamic sensors of drug-target interactions reveal kinase inhibitor specificities in living cells.

Taipale M, Krykbaeva I, Whitesell L, Santagata S, Zhang J, Liu Q, Gray NS, Lindquist S. Taipale M, et al. Among authors: santagata s. Nat Biotechnol. 2013 Jul;31(7):630-7. doi: 10.1038/nbt.2620. Epub 2013 Jun 30. Nat Biotechnol. 2013. PMID: 23811600 Free PMC article.

9

Tight coordination of protein translation and HSF1 activation supports the anabolic malignant state.

Santagata S, Mendillo ML, Tang YC, Subramanian A, Perley CC, Roche SP, Wong B, Narayan R, Kwon H, Koeva M, Amon A, Golub TR, Porco JA Jr, Whitesell L, Lindquist S. Santagata S, et al. Science. 2013 Jul 19;341(6143):1238303. doi: 10.1126/science.1238303. Science. 2013. PMID: 23869022 Free PMC article.

10

Structure-activity relationships for withanolides as inducers of the cellular heat-shock response.

Wijeratne EM, Xu YM, Scherz-Shouval R, Marron MT, Rocha DD, Liu MX, Costa-Lotufo LV, Santagata S, Lindquist S, Whitesell L, Gunatilaka AA. Wijeratne EM, et al. Among authors: santagata s. J Med Chem. 2014 Apr 10;57(7):2851-63. doi: 10.1021/jm401279n. Epub 2014 Mar 25. J Med Chem. 2014. PMID: 24625088

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