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SAR study of celastrol analogs targeting Nur77-mediated inflammatory pathway.
Chen Z, Zhang D, Yan S, Hu C, Huang Z, Li Z, Peng S, Li X, Zhu Y, Yu H, Lian B, Kang Q, Li M, Zeng Z, Zhang XK, Su Y. Chen Z, et al. Among authors: zhang d, zhang xk. Eur J Med Chem. 2019 Sep 1;177:171-187. doi: 10.1016/j.ejmech.2019.05.009. Epub 2019 May 12. Eur J Med Chem. 2019. PMID: 31132532
Antagonist analogue of 6-[3'-(1-adamantyl)-4'-hydroxyphenyl]-2-naphthalenecarboxylic acid (AHPN) family of apoptosis inducers that effectively blocks AHPN-induced apoptosis but not cell-cycle arrest.
Dawson MI, Harris DL, Liu G, Hobbs PD, Lange CW, Jong L, Bruey-Sedano N, James SY, Zhang XK, Peterson VJ, Leid M, Farhana L, Rishi AK, Fontana JA. Dawson MI, et al. Among authors: zhang xk. J Med Chem. 2004 Jul 1;47(14):3518-36. doi: 10.1021/jm030524k. J Med Chem. 2004. PMID: 15214780
Determinants of retinoid X receptor transcriptional antagonism.
Cavasotto CN, Liu G, James SY, Hobbs PD, Peterson VJ, Bhattacharya AA, Kolluri SK, Zhang XK, Leid M, Abagyan R, Liddington RC, Dawson MI. Cavasotto CN, et al. Among authors: zhang xk. J Med Chem. 2004 Aug 26;47(18):4360-72. doi: 10.1021/jm030651g. J Med Chem. 2004. PMID: 15317450
Targeting Nur77 translocation.
Zhang XK. Zhang XK. Expert Opin Ther Targets. 2007 Jan;11(1):69-79. doi: 10.1517/14728222.11.1.69. Expert Opin Ther Targets. 2007. PMID: 17150035 Review.
An adamantyl-substituted retinoid-derived molecule that inhibits cancer cell growth and angiogenesis by inducing apoptosis and binds to small heterodimer partner nuclear receptor: effects of modifying its carboxylate group on apoptosis, proliferation, and protein-tyrosine phosphatase activity.
Dawson MI, Xia Z, Liu G, Ye M, Fontana JA, Farhana L, Patel BB, Arumugarajah S, Bhuiyan M, Zhang XK, Han YH, Stallcup WB, Fukushi J, Mustelin T, Tautz L, Su Y, Harris DL, Waleh N, Hobbs PD, Jong L, Chao WR, Schiff LJ, Sani BP. Dawson MI, et al. Among authors: zhang xk. J Med Chem. 2007 May 31;50(11):2622-39. doi: 10.1021/jm0613323. Epub 2007 May 10. J Med Chem. 2007. PMID: 17489579 Free PMC article.
Adamantyl-substituted retinoid-derived molecules that interact with the orphan nuclear receptor small heterodimer partner: effects of replacing the 1-adamantyl or hydroxyl group on inhibition of cancer cell growth, induction of cancer cell apoptosis, and inhibition of SRC homology 2 domain-containing protein tyrosine phosphatase-2 activity.
Dawson MI, Xia Z, Jiang T, Ye M, Fontana JA, Farhana L, Patel B, Xue LP, Bhuiyan M, Pellicciari R, Macchiarulo A, Nuti R, Zhang XK, Han YH, Tautz L, Hobbs PD, Jong L, Waleh N, Chao WR, Feng GS, Pang Y, Su Y. Dawson MI, et al. Among authors: zhang xk. J Med Chem. 2008 Sep 25;51(18):5650-62. doi: 10.1021/jm800456k. Epub 2008 Aug 30. J Med Chem. 2008. PMID: 18759424 Free PMC article.
NSAID sulindac and its analog bind RXRalpha and inhibit RXRalpha-dependent AKT signaling.
Zhou H, Liu W, Su Y, Wei Z, Liu J, Kolluri SK, Wu H, Cao Y, Chen J, Wu Y, Yan T, Cao X, Gao W, Molotkov A, Jiang F, Li WG, Lin B, Zhang HP, Yu J, Luo SP, Zeng JZ, Duester G, Huang PQ, Zhang XK. Zhou H, et al. Among authors: zhang hp, zhang xk. Cancer Cell. 2010 Jun 15;17(6):560-73. doi: 10.1016/j.ccr.2010.04.023. Cancer Cell. 2010. PMID: 20541701 Free PMC article.
Targeting truncated retinoid X receptor-α by CF31 induces TNF-α-dependent apoptosis.
Wang GH, Jiang FQ, Duan YH, Zeng ZP, Chen F, Dai Y, Chen JB, Liu JX, Liu J, Zhou H, Chen HF, Zeng JZ, Su Y, Yao XS, Zhang XK. Wang GH, et al. Among authors: zhang xk. Cancer Res. 2013 Jan 1;73(1):307-18. doi: 10.1158/0008-5472.CAN-12-2038. Epub 2012 Nov 14. Cancer Res. 2013. PMID: 23151904 Free PMC article.
418 results