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Pharmacology and function of the orphan GPR139 G protein-coupled receptor.
Basic Clin Pharmacol Toxicol. 2020 Jun;126 Suppl 6(Suppl 6):35-46. doi: 10.1111/bcpt.13263. Epub 2019 Jun 27.
Basic Clin Pharmacol Toxicol. 2020.
PMID: 31132229
Free PMC article.
Review.
Novel Agonist Bioisosteres and Common Structure-Activity Relationships for The Orphan G Protein-Coupled Receptor GPR139.
Shehata MA, Nøhr AC, Lissa D, Bisig C, Isberg V, Andersen KB, Harpsøe K, Björkling F, Bräuner-Osborne H, Gloriam DE.
Shehata MA, et al. Among authors: nohr ac.
Sci Rep. 2016 Nov 10;6:36681. doi: 10.1038/srep36681.
Sci Rep. 2016.
PMID: 27830715
Free PMC article.
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The orphan G protein-coupled receptor GPR139 is activated by the peptides: Adrenocorticotropic hormone (ACTH), α-, and β-melanocyte stimulating hormone (α-MSH, and β-MSH), and the conserved core motif HFRW.
Nøhr AC, Shehata MA, Hauser AS, Isberg V, Mokrosinski J, Andersen KB, Farooqi IS, Pedersen DS, Gloriam DE, Bräuner-Osborne H.
Nøhr AC, et al.
Neurochem Int. 2017 Jan;102:105-113. doi: 10.1016/j.neuint.2016.11.012. Epub 2016 Dec 1.
Neurochem Int. 2017.
PMID: 27916541
Free PMC article.
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The GPR139 reference agonists 1a and 7c, and tryptophan and phenylalanine share a common binding site.
Nøhr AC, Jespers W, Shehata MA, Floryan L, Isberg V, Andersen KB, Åqvist J, Gutiérrez-de-Terán H, Bräuner-Osborne H, Gloriam DE.
Nøhr AC, et al.
Sci Rep. 2017 Apr 25;7(1):1128. doi: 10.1038/s41598-017-01049-z.
Sci Rep. 2017.
PMID: 28442765
Free PMC article.
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Identification of a novel scaffold for a small molecule GPR139 receptor agonist.
Nøhr AC, Shehata MA, Palmer D, Pokhrel R, Vallianou M, Foster SR, Gentry PR, Gloriam DE, Bräuner-Osborne H.
Nøhr AC, et al.
Sci Rep. 2019 Mar 7;9(1):3802. doi: 10.1038/s41598-019-40085-9.
Sci Rep. 2019.
PMID: 30846711
Free PMC article.
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Functional consequences of glucagon-like peptide-1 receptor cross-talk and trafficking.
Roed SN, Nøhr AC, Wismann P, Iversen H, Bräuner-Osborne H, Knudsen SM, Waldhoer M.
Roed SN, et al. Among authors: nohr ac.
J Biol Chem. 2015 Jan 9;290(2):1233-43. doi: 10.1074/jbc.M114.592436. Epub 2014 Dec 1.
J Biol Chem. 2015.
PMID: 25451942
Free PMC article.
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