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A nonsynonymous mutation in PLCG2 reduces the risk of Alzheimer's disease, dementia with Lewy bodies and frontotemporal dementia, and increases the likelihood of longevity.
van der Lee SJ, Conway OJ, Jansen I, Carrasquillo MM, Kleineidam L, van den Akker E, Hernández I, van Eijk KR, Stringa N, Chen JA, Zettergren A, Andlauer TFM, Diez-Fairen M, Simon-Sanchez J, Lleó A, Zetterberg H, Nygaard M, Blauwendraat C, Savage JE, Mengel-From J, Moreno-Grau S, Wagner M, Fortea J, Keogh MJ, Blennow K, Skoog I, Friese MA, Pletnikova O, Zulaica M, Lage C, de Rojas I, Riedel-Heller S, Illán-Gala I, Wei W, Jeune B, Orellana A, Then Bergh F, Wang X, Hulsman M, Beker N, Tesi N, Morris CM, Indakoetxea B, Collij LE, Scherer M, Morenas-Rodríguez E, Ironside JW, van Berckel BNM, Alcolea D, Wiendl H, Strickland SL, Pastor P, Rodríguez Rodríguez E; DESGESCO (Dementia Genetics Spanish Consortium), EADB (Alzheimer Disease European DNA biobank); EADB (Alzheimer Disease European DNA biobank); IFGC (International FTD-Genomics Consortium), IPDGC (The International Parkinson Disease Genomics Consortium); IPDGC (The International Parkinson Disease Genomics Consortium); RiMod-FTD (Risk and Modifying factors in Fronto-Temporal Dementia); Netherlands Brain Bank (NBB); Boeve BF, Petersen RC, Ferman TJ, van Gerpen JA, Reinders MJT, Uitti RJ, Tárraga L,… See abstract for full author list ➔ van der Lee SJ, et al. Among authors: van eijk kr, van den akker e, van schoor nm, van berckel bnm, van der flier wm, van gerpen ja. Acta Neuropathol. 2019 Aug;138(2):237-250. doi: 10.1007/s00401-019-02026-8. Epub 2019 May 27. Acta Neuropathol. 2019. PMID: 31131421 Free PMC article.
A 24-year follow-up of body mass index and cerebral atrophy.
de Leeuw FE, van der Flier WM, Scheltens P. de Leeuw FE, et al. Among authors: van der flier wm. Neurology. 2005 Jun 14;64(11):1990-1; author reply 1990-1. doi: 10.1212/wnl.64.11.1990. Neurology. 2005. PMID: 15955971 No abstract available.
Epidemiology and risk factors of dementia.
van der Flier WM, Scheltens P. van der Flier WM, et al. J Neurol Neurosurg Psychiatry. 2005 Dec;76 Suppl 5(Suppl 5):v2-7. doi: 10.1136/jnnp.2005.082867. J Neurol Neurosurg Psychiatry. 2005. PMID: 16291918 Free PMC article. Review. No abstract available.
Use of laboratory and imaging investigations in dementia.
van der Flier WM, Scheltens P. van der Flier WM, et al. J Neurol Neurosurg Psychiatry. 2005 Dec;76 Suppl 5(Suppl 5):v45-52. doi: 10.1136/jnnp.2005.082149. J Neurol Neurosurg Psychiatry. 2005. PMID: 16291921 Free PMC article. Review. No abstract available.
Hippocampal atrophy on MRI in frontotemporal lobar degeneration and Alzheimer's disease.
van de Pol LA, Hensel A, van der Flier WM, Visser PJ, Pijnenburg YA, Barkhof F, Gertz HJ, Scheltens P. van de Pol LA, et al. Among authors: van der flier wm. J Neurol Neurosurg Psychiatry. 2006 Apr;77(4):439-42. doi: 10.1136/jnnp.2005.075341. Epub 2005 Nov 23. J Neurol Neurosurg Psychiatry. 2006. PMID: 16306153 Free PMC article.
Infratentorial abnormalities in vascular dementia.
Bastos Leite AJ, van der Flier WM, van Straaten EC, Scheltens P, Barkhof F. Bastos Leite AJ, et al. Among authors: van der flier wm, van straaten ec. Stroke. 2006 Jan;37(1):105-10. doi: 10.1161/01.STR.0000196984.90718.8a. Epub 2005 Dec 8. Stroke. 2006. PMID: 16339463 Free article. Clinical Trial.
Multiple diagnostic tests are needed to assess multiple causes of dementia.
Olde Rikkert MG, van der Flier WM, de Leeuw FE, Verbeek M, Jansen RW, Verhey F, Scheltens P. Olde Rikkert MG, et al. Among authors: van der flier wm. Arch Neurol. 2006 Jan;63(1):144-6. doi: 10.1001/archneur.63.1.144. Arch Neurol. 2006. PMID: 16401751 No abstract available.
Hippocampal atrophy in Alzheimer disease: age matters.
van de Pol LA, Hensel A, Barkhof F, Gertz HJ, Scheltens P, van der Flier WM. van de Pol LA, et al. Among authors: van der flier wm. Neurology. 2006 Jan 24;66(2):236-8. doi: 10.1212/01.wnl.0000194240.47892.4d. Neurology. 2006. PMID: 16434661
701 results