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Recreation of in-host acquired single nucleotide polymorphisms by CRISPR-Cas9 reveals an uncharacterised gene playing a role in Aspergillus fumigatus azole resistance via a non-cyp51A mediated resistance mechanism.
Ballard E, Weber J, Melchers WJG, Tammireddy S, Whitfield PD, Brakhage AA, Brown AJP, Verweij PE, Warris A. Ballard E, et al. Among authors: whitfield pd. Fungal Genet Biol. 2019 Sep;130:98-106. doi: 10.1016/j.fgb.2019.05.005. Epub 2019 May 23. Fungal Genet Biol. 2019. PMID: 31128273 Free PMC article.
Fenretinide mediated retinoic acid receptor signalling and inhibition of ceramide biosynthesis regulates adipogenesis, lipid accumulation, mitochondrial function and nutrient stress signalling in adipocytes and adipose tissue.
Mcilroy GD, Tammireddy SR, Maskrey BH, Grant L, Doherty MK, Watson DG, Delibegović M, Whitfield PD, Mody N. Mcilroy GD, et al. Among authors: whitfield pd. Biochem Pharmacol. 2016 Jan 15;100:86-97. doi: 10.1016/j.bcp.2015.11.017. Epub 2015 Nov 22. Biochem Pharmacol. 2016. PMID: 26592777 Free PMC article.
Altered ceramide metabolism is a feature in the extracellular vesicle-mediated spread of alpha-synuclein in Lewy body disorders.
Kurzawa-Akanbi M, Tammireddy S, Fabrik I, Gliaudelytė L, Doherty MK, Heap R, Matečko-Burmann I, Burmann BM, Trost M, Lucocq JM, Gherman AV, Fairfoul G, Singh P, Burté F, Green A, McKeith IG, Härtlova A, Whitfield PD, Morris CM. Kurzawa-Akanbi M, et al. Among authors: whitfield pd. Acta Neuropathol. 2021 Dec;142(6):961-984. doi: 10.1007/s00401-021-02367-3. Epub 2021 Sep 13. Acta Neuropathol. 2021. PMID: 34514546 Free PMC article.
Neuronal human BACE1 knockin induces systemic diabetes in mice.
Plucińska K, Dekeryte R, Koss D, Shearer K, Mody N, Whitfield PD, Doherty MK, Mingarelli M, Welch A, Riedel G, Delibegovic M, Platt B. Plucińska K, et al. Among authors: whitfield pd. Diabetologia. 2016 Jul;59(7):1513-1523. doi: 10.1007/s00125-016-3960-1. Epub 2016 May 2. Diabetologia. 2016. PMID: 27138913 Free PMC article.
66 results