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315 results

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Effect of a Recombinant Human Soluble Thrombomodulin on Mortality in Patients With Sepsis-Associated Coagulopathy: The SCARLET Randomized Clinical Trial.
Vincent JL, Francois B, Zabolotskikh I, Daga MK, Lascarrou JB, Kirov MY, Pettilä V, Wittebole X, Meziani F, Mercier E, Lobo SM, Barie PS, Crowther M, Esmon CT, Fareed J, Gando S, Gorelick KJ, Levi M, Mira JP, Opal SM, Parrillo J, Russell JA, Saito H, Tsuruta K, Sakai T, Fineberg D; SCARLET Trial Group. Vincent JL, et al. Among authors: opal sm. JAMA. 2019 May 28;321(20):1993-2002. doi: 10.1001/jama.2019.5358. JAMA. 2019. PMID: 31104069 Free PMC article. Clinical Trial.
Effect of eritoran, an antagonist of MD2-TLR4, on mortality in patients with severe sepsis: the ACCESS randomized trial.
Opal SM, Laterre PF, Francois B, LaRosa SP, Angus DC, Mira JP, Wittebole X, Dugernier T, Perrotin D, Tidswell M, Jauregui L, Krell K, Pachl J, Takahashi T, Peckelsen C, Cordasco E, Chang CS, Oeyen S, Aikawa N, Maruyama T, Schein R, Kalil AC, Van Nuffelen M, Lynn M, Rossignol DP, Gogate J, Roberts MB, Wheeler JL, Vincent JL; ACCESS Study Group. Opal SM, et al. JAMA. 2013 Mar 20;309(11):1154-62. doi: 10.1001/jama.2013.2194. JAMA. 2013. PMID: 23512062 Clinical Trial.
Effect of Selepressin vs Placebo on Ventilator- and Vasopressor-Free Days in Patients With Septic Shock: The SEPSIS-ACT Randomized Clinical Trial.
Laterre PF, Berry SM, Blemings A, Carlsen JE, François B, Graves T, Jacobsen K, Lewis RJ, Opal SM, Perner A, Pickkers P, Russell JA, Windeløv NA, Yealy DM, Asfar P, Bestle MH, Muller G, Bruel C, Brulé N, Decruyenaere J, Dive AM, Dugernier T, Krell K, Lefrant JY, Megarbane B, Mercier E, Mira JP, Quenot JP, Rasmussen BS, Thorsen-Meyer HC, Vander Laenen M, Vang ML, Vignon P, Vinatier I, Wichmann S, Wittebole X, Kjølbye AL, Angus DC; SEPSIS-ACT Investigators. Laterre PF, et al. Among authors: opal sm. JAMA. 2019 Oct 15;322(15):1476-1485. doi: 10.1001/jama.2019.14607. JAMA. 2019. PMID: 31577035 Free PMC article.
Biomarkers of Infection and Sepsis.
Opal SM, Wittebole X. Opal SM, et al. Crit Care Clin. 2020 Jan;36(1):11-22. doi: 10.1016/j.ccc.2019.08.002. Epub 2019 Oct 21. Crit Care Clin. 2020. PMID: 31733673 Review.
Coagulation in sepsis.
Amaral A, Opal SM, Vincent JL. Amaral A, et al. Among authors: opal sm. Intensive Care Med. 2004 Jun;30(6):1032-40. doi: 10.1007/s00134-004-2291-8. Epub 2004 May 18. Intensive Care Med. 2004. PMID: 15148567 Review.
Sepsis definitions: time for change.
Vincent JL, Opal SM, Marshall JC, Tracey KJ. Vincent JL, et al. Among authors: opal sm. Lancet. 2013 Mar 2;381(9868):774-5. doi: 10.1016/S0140-6736(12)61815-7. Lancet. 2013. PMID: 23472921 Free PMC article. No abstract available.
The Third International Consensus Definitions for Sepsis and Septic Shock (Sepsis-3).
Singer M, Deutschman CS, Seymour CW, Shankar-Hari M, Annane D, Bauer M, Bellomo R, Bernard GR, Chiche JD, Coopersmith CM, Hotchkiss RS, Levy MM, Marshall JC, Martin GS, Opal SM, Rubenfeld GD, van der Poll T, Vincent JL, Angus DC. Singer M, et al. Among authors: opal sm. JAMA. 2016 Feb 23;315(8):801-10. doi: 10.1001/jama.2016.0287. JAMA. 2016. PMID: 26903338 Free PMC article.
Sepsis and septic shock.
Hotchkiss RS, Moldawer LL, Opal SM, Reinhart K, Turnbull IR, Vincent JL. Hotchkiss RS, et al. Among authors: opal sm. Nat Rev Dis Primers. 2016 Jun 30;2:16045. doi: 10.1038/nrdp.2016.45. Nat Rev Dis Primers. 2016. PMID: 28117397 Free PMC article. Review.
315 results