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Reactivation of PTEN tumor suppressor for cancer treatment through inhibition of a MYC-WWP1 inhibitory pathway.
Lee YR, Chen M, Lee JD, Zhang J, Lin SY, Fu TM, Chen H, Ishikawa T, Chiang SY, Katon J, Zhang Y, Shulga YV, Bester AC, Fung J, Monteleone E, Wan L, Shen C, Hsu CH, Papa A, Clohessy JG, Teruya-Feldstein J, Jain S, Wu H, Matesic L, Chen RH, Wei W, Pandolfi PP. Lee YR, et al. Among authors: chen m, chen rh, chen h. Science. 2019 May 17;364(6441):eaau0159. doi: 10.1126/science.aau0159. Science. 2019. PMID: 31097636 Free PMC article.
Pills of PTEN? In and out for tumor suppression.
Papa A, Chen M, Pandolfi PP. Papa A, et al. Among authors: chen m. Cell Res. 2013 Oct;23(10):1155-6. doi: 10.1038/cr.2013.103. Epub 2013 Aug 6. Cell Res. 2013. PMID: 23917528 Free PMC article.
DOK2 inhibits EGFR-mutated lung adenocarcinoma.
Berger AH, Chen M, Morotti A, Janas JA, Niki M, Bronson RT, Taylor BS, Ladanyi M, Van Aelst L, Politi K, Varmus HE, Pandolfi PP. Berger AH, et al. Among authors: chen m. PLoS One. 2013 Nov 8;8(11):e79526. doi: 10.1371/journal.pone.0079526. eCollection 2013. PLoS One. 2013. PMID: 24255704 Free PMC article.
Vulnerabilities of PTEN-TP53-deficient prostate cancers to compound PARP-PI3K inhibition.
González-Billalabeitia E, Seitzer N, Song SJ, Song MS, Patnaik A, Liu XS, Epping MT, Papa A, Hobbs RM, Chen M, Lunardi A, Ng C, Webster KA, Signoretti S, Loda M, Asara JM, Nardella C, Clohessy JG, Cantley LC, Pandolfi PP. González-Billalabeitia E, et al. Among authors: chen m. Cancer Discov. 2014 Aug;4(8):896-904. doi: 10.1158/2159-8290.CD-13-0230. Epub 2014 May 27. Cancer Discov. 2014. PMID: 24866151 Free PMC article.
Suppression of CHK1 by ETS Family Members Promotes DNA Damage Response Bypass and Tumorigenesis.
Lunardi A, Varmeh S, Chen M, Taulli R, Guarnerio J, Ala U, Seitzer N, Ishikawa T, Carver BS, Hobbs RM, Quarantotti V, Ng C, Berger AH, Nardella C, Poliseno L, Montironi R, Castillo-Martin M, Cordon-Cardo C, Signoretti S, Pandolfi PP. Lunardi A, et al. Among authors: chen m. Cancer Discov. 2015 May;5(5):550-63. doi: 10.1158/2159-8290.CD-13-1050. Epub 2015 Feb 4. Cancer Discov. 2015. PMID: 25653093 Free PMC article.
In Vivo Role of INPP4B in Tumor and Metastasis Suppression through Regulation of PI3K-AKT Signaling at Endosomes.
Li Chew C, Lunardi A, Gulluni F, Ruan DT, Chen M, Salmena L, Nishino M, Papa A, Ng C, Fung J, Clohessy JG, Sasaki J, Sasaki T, Bronson RT, Hirsch E, Pandolfi PP. Li Chew C, et al. Among authors: chen m. Cancer Discov. 2015 Jul;5(7):740-51. doi: 10.1158/2159-8290.CD-14-1347. Epub 2015 Apr 16. Cancer Discov. 2015. PMID: 25883022 Free PMC article.
Endosome and INPP4B.
Chew CL, Chen M, Pandolfi PP. Chew CL, et al. Among authors: chen m. Oncotarget. 2016 Jan 5;7(1):5-6. doi: 10.18632/oncotarget.6663. Oncotarget. 2016. PMID: 26700619 Free PMC article. No abstract available.
The APC/C E3 Ligase Complex Activator FZR1 Restricts BRAF Oncogenic Function.
Wan L, Chen M, Cao J, Dai X, Yin Q, Zhang J, Song SJ, Lu Y, Liu J, Inuzuka H, Katon JM, Berry K, Fung J, Ng C, Liu P, Song MS, Xue L, Bronson RT, Kirschner MW, Cui R, Pandolfi PP, Wei W. Wan L, et al. Among authors: chen m. Cancer Discov. 2017 Apr;7(4):424-441. doi: 10.1158/2159-8290.CD-16-0647. Epub 2017 Feb 7. Cancer Discov. 2017. PMID: 28174173 Free PMC article.
Preclinical and Coclinical Studies in Prostate Cancer.
Chen M, Pandolfi PP. Chen M, et al. Cold Spring Harb Perspect Med. 2018 Apr 2;8(4):a030544. doi: 10.1101/cshperspect.a030544. Cold Spring Harb Perspect Med. 2018. PMID: 29038335 Free PMC article. Review.
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