Clarke AR - Search Results

1

Rapid activation of epithelial-mesenchymal transition drives PARP inhibitor resistance in Brca2-mutant mammary tumours.

Ordonez LD, Hay T, McEwen R, Polanska UM, Hughes A, Delpuech O, Cadogan E, Powell S, Dry J, Tornillo G, Silcock L, Leo E, O'Connor MJ, Clarke AR, Smalley MJ. Ordonez LD, et al. Among authors: clarke ar. Oncotarget. 2019 Apr 5;10(27):2586-2606. doi: 10.18632/oncotarget.26830. eCollection 2019 Apr 5. Oncotarget. 2019. PMID: 31080552 Free PMC article.

2

APC2 is critical for ovarian WNT signalling control, fertility and tumour suppression.

Mohamed NE, Hay T, Reed KR, Smalley MJ, Clarke AR. Mohamed NE, et al. Among authors: clarke ar. BMC Cancer. 2019 Jul 10;19(1):677. doi: 10.1186/s12885-019-5867-y. BMC Cancer. 2019. PMID: 31291912 Free PMC article.

3

Poly(ADP-ribose) polymerase-1 inhibitor treatment regresses autochthonous Brca2/p53-mutant mammary tumors in vivo and delays tumor relapse in combination with carboplatin.

Hay T, Matthews JR, Pietzka L, Lau A, Cranston A, Nygren AO, Douglas-Jones A, Smith GC, Martin NM, O'Connor M, Clarke AR. Hay T, et al. Among authors: clarke ar. Cancer Res. 2009 May 1;69(9):3850-5. doi: 10.1158/0008-5472.CAN-08-2388. Epub 2009 Apr 21. Cancer Res. 2009. PMID: 19383921

4

PTEN loss and activation of K-RAS and β-catenin cooperate to accelerate prostate tumourigenesis.

Jefferies MT, Cox AC, Shorning BY, Meniel V, Griffiths D, Kynaston HG, Smalley MJ, Clarke AR. Jefferies MT, et al. Among authors: clarke ar. J Pathol. 2017 Dec;243(4):442-456. doi: 10.1002/path.4977. Epub 2017 Nov 14. J Pathol. 2017. PMID: 29134654 Free PMC article.

5

DNA damage hypersensitivity in cells lacking BRCA2: a review of in vitro and in vivo data.

Hay T, Clarke AR. Hay T, et al. Among authors: clarke ar. Biochem Soc Trans. 2005 Aug;33(Pt 4):715-7. doi: 10.1042/BST0330715. Biochem Soc Trans. 2005. PMID: 16042582 Review.

6

Brca2 deficiency in the murine small intestine sensitizes to p53-dependent apoptosis and leads to the spontaneous deletion of stem cells.

Hay T, Patrick T, Winton D, Sansom OJ, Clarke AR. Hay T, et al. Among authors: clarke ar. Oncogene. 2005 May 26;24(23):3842-6. doi: 10.1038/sj.onc.1208533. Oncogene. 2005. PMID: 15735671

7

Efficient deletion of normal Brca2-deficient intestinal epithelium by poly(ADP-ribose) polymerase inhibition models potential prophylactic therapy.

Hay T, Jenkins H, Sansom OJ, Martin NM, Smith GC, Clarke AR. Hay T, et al. Among authors: clarke ar. Cancer Res. 2005 Nov 15;65(22):10145-8. doi: 10.1158/0008-5472.CAN-05-1186. Cancer Res. 2005. PMID: 16287996

8

What are the best routes to effectively model human colorectal cancer?

Young M, Ordonez L, Clarke AR. Young M, et al. Among authors: clarke ar. Mol Oncol. 2013 Apr;7(2):178-89. doi: 10.1016/j.molonc.2013.02.006. Epub 2013 Feb 20. Mol Oncol. 2013. PMID: 23465602 Free PMC article. Review.

9

Functional redundancy between Apc and Apc2 regulates tissue homeostasis and prevents tumorigenesis in murine mammary epithelium.

Daly CS, Shaw P, Ordonez LD, Williams GT, Quist J, Grigoriadis A, Van Es JH, Clevers H, Clarke AR, Reed KR. Daly CS, et al. Among authors: clarke ar. Oncogene. 2017 Mar 30;36(13):1793-1803. doi: 10.1038/onc.2016.342. Epub 2016 Oct 3. Oncogene. 2017. PMID: 27694902 Free PMC article.

10

Mutations in Apc and p53 synergize to promote mammary neoplasia.

Méniel V, Hay T, Douglas-Jones A, Sansom OJ, Clarke AR. Méniel V, et al. Among authors: clarke ar. Cancer Res. 2005 Jan 15;65(2):410-6. Cancer Res. 2005. PMID: 15695381

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