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The triacylglycerol, hydroxytriolein, inhibits triple negative mammary breast cancer cell proliferation through a mechanism dependent on dihydroceramide and Akt.
Oncotarget. 2019 Apr 2;10(26):2486-2507. doi: 10.18632/oncotarget.26824. eCollection 2019 Apr 2.
Oncotarget. 2019.
PMID: 31069012
Free PMC article.
The Novel Anticancer Drug Hydroxytriolein Inhibits Lung Cancer Cell Proliferation via a Protein Kinase Cα- and Extracellular Signal-Regulated Kinase 1/2-Dependent Mechanism.
Guardiola-Serrano F, Beteta-Göbel R, Rodríguez-Lorca R, Ibarguren M, López DJ, Terés S, Alvarez R, Alonso-Sande M, Busquets X, Escribá PV.
Guardiola-Serrano F, et al. Among authors: alonso sande m.
J Pharmacol Exp Ther. 2015 Aug;354(2):213-24. doi: 10.1124/jpet.114.222281. Epub 2015 Jun 11.
J Pharmacol Exp Ther. 2015.
PMID: 26065701
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Differential effect of 2-hydroxyoleic acid enantiomers on protein (sphingomyelin synthase) and lipid (membrane) targets.
Piotto S, Concilio S, Bianchino E, Iannelli P, López DJ, Terés S, Ibarguren M, Barceló-Coblijn G, Martin ML, Guardiola-Serrano F, Alonso-Sande M, Funari SS, Busquets X, Escribá PV.
Piotto S, et al. Among authors: alonso sande m.
Biochim Biophys Acta. 2014 Jun;1838(6):1628-37. doi: 10.1016/j.bbamem.2013.12.023. Epub 2014 Jan 9.
Biochim Biophys Acta. 2014.
PMID: 24412218
Free article.
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Sustained activation of sphingomyelin synthase by 2-hydroxyoleic acid induces sphingolipidosis in tumor cells.
Martin ML, Liebisch G, Lehneis S, Schmitz G, Alonso-Sande M, Bestard-Escalas J, Lopez DH, García-Verdugo JM, Soriano-Navarro M, Busquets X, Escribá PV, Barceló-Coblijn G.
Martin ML, et al. Among authors: alonso sande m.
J Lipid Res. 2013 May;54(5):1457-65. doi: 10.1194/jlr.M036749. Epub 2013 Mar 7.
J Lipid Res. 2013.
PMID: 23471028
Free PMC article.
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PEGylated lipid nanocapsules with improved drug encapsulation and controlled release properties.
Hervella P, Alonso-Sande M, Ledo F, Lucero ML, Alonso MJ, Garcia-Fuentes M.
Hervella P, et al. Among authors: alonso sande m.
Curr Top Med Chem. 2014;14(9):1115-23. doi: 10.2174/1568026614666140329224716.
Curr Top Med Chem. 2014.
PMID: 24678710
Free article.
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Development of PLGA-mannosamine nanoparticles as oral protein carriers.
Alonso-Sande M, des Rieux A, Fievez V, Sarmento B, Delgado A, Evora C, Remuñán-López C, Préat V, Alonso MJ.
Alonso-Sande M, et al.
Biomacromolecules. 2013 Nov 11;14(11):4046-52. doi: 10.1021/bm401141u. Epub 2013 Oct 30.
Biomacromolecules. 2013.
PMID: 24131254
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Glucomannan, a promising polysaccharide for biopharmaceutical purposes.
Alonso-Sande M, Teijeiro-Osorio D, Remuñán-López C, Alonso MJ.
Alonso-Sande M, et al.
Eur J Pharm Biopharm. 2009 Jun;72(2):453-62. doi: 10.1016/j.ejpb.2008.02.005. Epub 2008 Feb 16.
Eur J Pharm Biopharm. 2009.
PMID: 18511246
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Helodermin-loaded nanoparticles: characterization and transport across an in vitro model of the follicle-associated epithelium.
des Rieux A, Fievez V, Momtaz M, Detrembleur C, Alonso-Sande M, Van Gelder J, Cauvin A, Schneider YJ, Préat V.
des Rieux A, et al. Among authors: alonso sande m.
J Control Release. 2007 Apr 23;118(3):294-302. doi: 10.1016/j.jconrel.2006.12.023. Epub 2006 Dec 29.
J Control Release. 2007.
PMID: 17292503
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