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Discovery of short-course antiwolbachial quinazolines for elimination of filarial worm infections.
Sci Transl Med. 2019 May 8;11(491):eaav3523. doi: 10.1126/scitranslmed.aav3523.
Sci Transl Med. 2019.
PMID: 31068442
AWZ1066S, a highly specific anti-Wolbachia drug candidate for a short-course treatment of filariasis.
Hong WD, Benayoud F, Nixon GL, Ford L, Johnston KL, Clare RH, Cassidy A, Cook DAN, Siu A, Shiotani M, Webborn PJH, Kavanagh S, Aljayyoussi G, Murphy E, Steven A, Archer J, Struever D, Frohberger SJ, Ehrens A, Hübner MP, Hoerauf A, Roberts AP, Hubbard ATM, Tate EW, Serwa RA, Leung SC, Qie L, Berry NG, Gusovsky F, Hemingway J, Turner JD, Taylor MJ, Ward SA, O'Neill PM.
Hong WD, et al. Among authors: struever d.
Proc Natl Acad Sci U S A. 2019 Jan 22;116(4):1414-1419. doi: 10.1073/pnas.1816585116. Epub 2019 Jan 7.
Proc Natl Acad Sci U S A. 2019.
PMID: 30617067
Free PMC article.
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Discovery of ABBV-4083, a novel analog of Tylosin A that has potent anti-Wolbachia and anti-filarial activity.
von Geldern TW, Morton HE, Clark RF, Brown BS, Johnston KL, Ford L, Specht S, Carr RA, Stolarik DF, Ma J, Rieser MJ, Struever D, Frohberger SJ, Koschel M, Ehrens A, Turner JD, Hübner MP, Hoerauf A, Taylor MJ, Ward SA, Marsh K, Kempf DJ.
von Geldern TW, et al. Among authors: struever d.
PLoS Negl Trop Dis. 2019 Feb 28;13(2):e0007159. doi: 10.1371/journal.pntd.0007159. eCollection 2019 Feb.
PLoS Negl Trop Dis. 2019.
PMID: 30818326
Free PMC article.
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In vivo kinetics of Wolbachia depletion by ABBV-4083 in L. sigmodontis adult worms and microfilariae.
Hübner MP, Koschel M, Struever D, Nikolov V, Frohberger SJ, Ehrens A, Fendler M, Johannes I, von Geldern TW, Marsh K, Turner JD, Taylor MJ, Ward SA, Pfarr K, Kempf DJ, Hoerauf A.
Hübner MP, et al. Among authors: struever d.
PLoS Negl Trop Dis. 2019 Aug 5;13(8):e0007636. doi: 10.1371/journal.pntd.0007636. eCollection 2019 Aug.
PLoS Negl Trop Dis. 2019.
PMID: 31381563
Free PMC article.
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In vivo efficacy of the boron-pleuromutilin AN11251 against Wolbachia of the rodent filarial nematode Litomosoides sigmodontis.
Ehrens A, Lunde CS, Jacobs RT, Struever D, Koschel M, Frohberger SJ, Lenz F, Fendler M, Turner JD, Ward SA, Taylor MJ, Freund YR, Stefanakis R, Easom E, Li X, Plattner JJ, Hoerauf A, Hübner MP.
Ehrens A, et al. Among authors: struever d.
PLoS Negl Trop Dis. 2020 Jan 27;14(1):e0007957. doi: 10.1371/journal.pntd.0007957. eCollection 2020 Jan.
PLoS Negl Trop Dis. 2020.
PMID: 31986143
Free PMC article.
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Oxfendazole mediates macrofilaricidal efficacy against the filarial nematode Litomosoides sigmodontis in vivo and inhibits Onchocerca spec. motility in vitro.
Hübner MP, Martin C, Specht S, Koschel M, Dubben B, Frohberger SJ, Ehrens A, Fendler M, Struever D, Mitre E, Vallarino-Lhermitte N, Gokool S, Lustigman S, Schneider M, Townson S, Hoerauf A, Scandale I.
Hübner MP, et al. Among authors: struever d.
PLoS Negl Trop Dis. 2020 Jul 6;14(7):e0008427. doi: 10.1371/journal.pntd.0008427. eCollection 2020 Jul.
PLoS Negl Trop Dis. 2020.
PMID: 32628671
Free PMC article.
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Effect of DNA repair host factors on temozolomide or dacarbazine melanoma treatment in Caucasians.
Boeckmann L, Schirmer M, Rosenberger A, Struever D, Thoms KM, Gutzmer R, Has C, Kunz M, Kuschal C, Laspe P, Schoen MP, Brockmoeller J, Emmert S.
Boeckmann L, et al. Among authors: struever d.
Pharmacogenet Genomics. 2009 Oct;19(10):760-9. doi: 10.1097/FPC.0b013e3283307cd9.
Pharmacogenet Genomics. 2009.
PMID: 19741564
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Modulation of the efficacy of temozolomide and dacarbazine melanoma treatment by DNA-repair factors in vivo and in vitro.
Boeckmann L, Thoms KM, Gutzmer R, Has C, Kunz M, Kuschal C, Laspe P, Struever D, Emmert S.
Boeckmann L, et al. Among authors: struever d.
Int J Clin Pharmacol Ther. 2009 Jan;47(1):33-5. doi: 10.5414/cpp47033.
Int J Clin Pharmacol Ther. 2009.
PMID: 19203531
No abstract available.
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