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Rapid Covalent-Probe Discovery by Electrophile-Fragment Screening.
Resnick E, Bradley A, Gan J, Douangamath A, Krojer T, Sethi R, Geurink PP, Aimon A, Amitai G, Bellini D, Bennett J, Fairhead M, Fedorov O, Gabizon R, Gan J, Guo J, Plotnikov A, Reznik N, Ruda GF, Díaz-Sáez L, Straub VM, Szommer T, Velupillai S, Zaidman D, Zhang Y, Coker AR, Dowson CG, Barr HM, Wang C, Huber KVM, Brennan PE, Ovaa H, von Delft F, London N. Resnick E, et al. Among authors: von delft f. J Am Chem Soc. 2019 Jun 5;141(22):8951-8968. doi: 10.1021/jacs.9b02822. Epub 2019 May 22. J Am Chem Soc. 2019. PMID: 31060360 Free PMC article.
Structural and mechanistic studies on γ-butyrobetaine hydroxylase.
Leung IK, Krojer TJ, Kochan GT, Henry L, von Delft F, Claridge TD, Oppermann U, McDonough MA, Schofield CJ. Leung IK, et al. Among authors: von delft f. Chem Biol. 2010 Dec 22;17(12):1316-24. doi: 10.1016/j.chembiol.2010.09.016. Chem Biol. 2010. PMID: 21168767
Crystal structures of the endoplasmic reticulum aminopeptidase-1 (ERAP1) reveal the molecular basis for N-terminal peptide trimming.
Kochan G, Krojer T, Harvey D, Fischer R, Chen L, Vollmar M, von Delft F, Kavanagh KL, Brown MA, Bowness P, Wordsworth P, Kessler BM, Oppermann U. Kochan G, et al. Among authors: von delft f. Proc Natl Acad Sci U S A. 2011 May 10;108(19):7745-50. doi: 10.1073/pnas.1101262108. Epub 2011 Apr 20. Proc Natl Acad Sci U S A. 2011. PMID: 21508329 Free PMC article.
Squeezing the most from every crystal: the fine details of data collection.
Krojer T, Pike AC, von Delft F. Krojer T, et al. Among authors: von delft f. Acta Crystallogr D Biol Crystallogr. 2013 Jul;69(Pt 7):1303-13. doi: 10.1107/S0907444913013280. Epub 2013 Jun 18. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23793157 Free PMC article.
8-Substituted Pyrido[3,4-d]pyrimidin-4(3H)-one Derivatives As Potent, Cell Permeable, KDM4 (JMJD2) and KDM5 (JARID1) Histone Lysine Demethylase Inhibitors.
Bavetsias V, Lanigan RM, Ruda GF, Atrash B, McLaughlin MG, Tumber A, Mok NY, Le Bihan YV, Dempster S, Boxall KJ, Jeganathan F, Hatch SB, Savitsky P, Velupillai S, Krojer T, England KS, Sejberg J, Thai C, Donovan A, Pal A, Scozzafava G, Bennett JM, Kawamura A, Johansson C, Szykowska A, Gileadi C, Burgess-Brown NA, von Delft F, Oppermann U, Walters Z, Shipley J, Raynaud FI, Westaway SM, Prinjha RK, Fedorov O, Burke R, Schofield CJ, Westwood IM, Bountra C, Müller S, van Montfort RL, Brennan PE, Blagg J. Bavetsias V, et al. Among authors: von delft f. J Med Chem. 2016 Feb 25;59(4):1388-409. doi: 10.1021/acs.jmedchem.5b01635. Epub 2016 Jan 7. J Med Chem. 2016. PMID: 26741168 Free PMC article.
An overview of heavy-atom derivatization of protein crystals.
Pike AC, Garman EF, Krojer T, von Delft F, Carpenter EP. Pike AC, et al. Among authors: von delft f. Acta Crystallogr D Struct Biol. 2016 Mar;72(Pt 3):303-18. doi: 10.1107/S2059798316000401. Epub 2016 Mar 1. Acta Crystallogr D Struct Biol. 2016. PMID: 26960118 Free PMC article. Review.
154 results