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The utility of a differentiated preclinical liver model, HepaRG cells, in investigating delayed toxicity via inhibition of mitochondrial-replication induced by fialuridine.
Jolly CE, Douglas O, Kamalian L, Jenkins RE, Beckett AJ, Penman SL, Williams DP, Monshouwer M, Simic D, Snoeys J, Park BK, Chadwick AE. Jolly CE, et al. Toxicol Appl Pharmacol. 2020 Sep 15;403:115163. doi: 10.1016/j.taap.2020.115163. Epub 2020 Jul 28. Toxicol Appl Pharmacol. 2020. PMID: 32730777 Free PMC article.
Mucosal-associated invariant T (MAIT) cells are activated in the gastrointestinal tissue of patients with combination ipilimumab and nivolumab therapy-related colitis in a pathology distinct from ulcerative colitis.
Sasson SC, Zaunders JJ, Nahar K, Munier CML, Fairfax BP, Olsson-Brown A, Jolly C, Read SA, Ahlenstiel G, Palendira U, Scolyer RA, Carlino MS, Payne MJ, Cheung VTF, Gupta T, Klenerman P, Long GV, Brain O, Menzies AM, Kelleher AD. Sasson SC, et al. Clin Exp Immunol. 2020 Dec;202(3):335-352. doi: 10.1111/cei.13502. Epub 2020 Aug 19. Clin Exp Immunol. 2020. PMID: 32734627 Free PMC article. Clinical Trial.
16 results