Nicolaes GAF - Search Results

1

Externalized histone H4 orchestrates chronic inflammation by inducing lytic cell death.

Silvestre-Roig C, Braster Q, Wichapong K, Lee EY, Teulon JM, Berrebeh N, Winter J, Adrover JM, Santos GS, Froese A, Lemnitzer P, Ortega-Gómez A, Chevre R, Marschner J, Schumski A, Winter C, Perez-Olivares L, Pan C, Paulin N, Schoufour T, Hartwig H, González-Ramos S, Kamp F, Megens RTA, Mowen KA, Gunzer M, Maegdefessel L, Hackeng T, Lutgens E, Daemen M, von Blume J, Anders HJ, Nikolaev VO, Pellequer JL, Weber C, Hidalgo A, Nicolaes GAF, Wong GCL, Soehnlein O. Silvestre-Roig C, et al. Among authors: nicolaes gaf. Nature. 2019 May;569(7755):236-240. doi: 10.1038/s41586-019-1167-6. Epub 2019 May 1. Nature. 2019. PMID: 31043745 Free PMC article.

2

Re-evaluation of the role of the protein S-C4b binding protein complex in activated protein C-catalyzed factor Va-inactivation.

Maurissen LF, Thomassen MC, Nicolaes GA, Dahlbäck B, Tans G, Rosing J, Hackeng TM. Maurissen LF, et al. Blood. 2008 Mar 15;111(6):3034-41. doi: 10.1182/blood-2007-06-089987. Epub 2007 Dec 26. Blood. 2008. PMID: 18160668 Free article.

3

The structure-function relationship of activated protein C. Lessons from natural and engineered mutations.

Wildhagen KC, Lutgens E, Loubele ST, ten Cate H, Nicolaes GA. Wildhagen KC, et al. Thromb Haemost. 2011 Dec;106(6):1034-45. doi: 10.1160/TH11-08-0522. Epub 2011 Nov 10. Thromb Haemost. 2011. PMID: 22072231 Review.

4

Optimization of compound ranking for structure-based virtual ligand screening using an established FRED-Surflex consensus approach.

Du J, Bleylevens IW, Bitorina AV, Wichapong K, Nicolaes GA. Du J, et al. Chem Biol Drug Des. 2014 Jan;83(1):37-51. doi: 10.1111/cbdd.12202. Epub 2013 Oct 4. Chem Biol Drug Des. 2014. PMID: 23941463

5

Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis.

Wildhagen KC, García de Frutos P, Reutelingsperger CP, Schrijver R, Aresté C, Ortega-Gómez A, Deckers NM, Hemker HC, Soehnlein O, Nicolaes GA. Wildhagen KC, et al. Blood. 2014 Feb 13;123(7):1098-101. doi: 10.1182/blood-2013-07-514984. Epub 2013 Nov 21. Blood. 2014. PMID: 24264231 Free article.

6

Effects of exogenous recombinant APC in mouse models of ischemia reperfusion injury and of atherosclerosis.

Wildhagen KC, Schrijver R, Beckers L, ten Cate H, Reutelingsperger CP, Lutgens E, Nicolaes GA. Wildhagen KC, et al. PLoS One. 2014 Jul 17;9(7):e101446. doi: 10.1371/journal.pone.0101446. eCollection 2014. PLoS One. 2014. PMID: 25032959 Free PMC article.

7

Molecular simulation studies of human coagulation factor VIII C domain-mediated membrane binding.

Du J, Wichapong K, Hackeng KM, Nicolaes GA. Du J, et al. Thromb Haemost. 2015 Feb;113(2):373-84. doi: 10.1160/TH14-02-0180. Epub 2014 Oct 30. Thromb Haemost. 2015. PMID: 25354705

8

Blocking CD40-TRAF6 interactions by small-molecule inhibitor 6860766 ameliorates the complications of diet-induced obesity in mice.

van den Berg SM, Seijkens TT, Kusters PJ, Zarzycka B, Beckers L, den Toom M, Gijbels MJ, Chatzigeorgiou A, Weber C, de Winther MP, Chavakis T, Nicolaes GA, Lutgens E. van den Berg SM, et al. Int J Obes (Lond). 2015 May;39(5):782-90. doi: 10.1038/ijo.2014.198. Epub 2014 Nov 13. Int J Obes (Lond). 2015. PMID: 25394307

9

Discovery of small molecule CD40-TRAF6 inhibitors.

Zarzycka B, Seijkens T, Nabuurs SB, Ritschel T, Grommes J, Soehnlein O, Schrijver R, van Tiel CM, Hackeng TM, Weber C, Giehler F, Kieser A, Lutgens E, Vriend G, Nicolaes GA. Zarzycka B, et al. J Chem Inf Model. 2015 Feb 23;55(2):294-307. doi: 10.1021/ci500631e. Epub 2015 Jan 27. J Chem Inf Model. 2015. PMID: 25622654

10

Targeting the adaptive immune system: new strategies in the treatment of atherosclerosis.

Zarzycka B, Nicolaes GA, Lutgens E. Zarzycka B, et al. Expert Rev Clin Pharmacol. 2015 May;8(3):297-313. doi: 10.1586/17512433.2015.1025052. Epub 2015 Apr 4. Expert Rev Clin Pharmacol. 2015. PMID: 25843158 Review.

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