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Androgen receptor-modulatory microRNAs provide insight into therapy resistance and therapeutic targets in advanced prostate cancer.
Fletcher CE, Sulpice E, Combe S, Shibakawa A, Leach DA, Hamilton MP, Chrysostomou SL, Sharp A, Welti J, Yuan W, Dart DA, Knight E, Ning J, Francis JC, Kounatidou EE, Gaughan L, Swain A, Lupold SE, de Bono JS, McGuire SE, Gidrol X, Bevan CL. Fletcher CE, et al. Among authors: gaughan l. Oncogene. 2019 Jul;38(28):5700-5724. doi: 10.1038/s41388-019-0823-5. Epub 2019 May 1. Oncogene. 2019. PMID: 31043708 Free PMC article.
The lysine demethylase, KDM4B, is a key molecule in androgen receptor signalling and turnover.
Coffey K, Rogerson L, Ryan-Munden C, Alkharaif D, Stockley J, Heer R, Sahadevan K, O'Neill D, Jones D, Darby S, Staller P, Mantilla A, Gaughan L, Robson CN. Coffey K, et al. Among authors: gaughan l. Nucleic Acids Res. 2013 Apr;41(8):4433-46. doi: 10.1093/nar/gkt106. Epub 2013 Feb 21. Nucleic Acids Res. 2013. PMID: 23435229 Free PMC article.
Deubiquitinating enzyme Usp12 is a novel co-activator of the androgen receptor.
Burska UL, Harle VJ, Coffey K, Darby S, Ramsey H, O'Neill D, Logan IR, Gaughan L, Robson CN. Burska UL, et al. Among authors: gaughan l. J Biol Chem. 2013 Nov 8;288(45):32641-32650. doi: 10.1074/jbc.M113.485912. Epub 2013 Sep 21. J Biol Chem. 2013. PMID: 24056413 Free PMC article.
The co-chaperone p23 promotes prostate cancer motility and metastasis.
Cano LQ, Lavery DN, Sin S, Spanjaard E, Brooke GN, Tilman JD, Abroaf A, Gaughan L, Robson CN, Heer R, Mauri F, de Rooij J, Driouch K, Bevan CL. Cano LQ, et al. Among authors: gaughan l. Mol Oncol. 2015 Jan;9(1):295-308. doi: 10.1016/j.molonc.2014.08.014. Epub 2014 Sep 6. Mol Oncol. 2015. PMID: 25241147 Free PMC article.
71 results