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Novel selective agonist of GPR18, PSB-KK-1415 exerts potent anti-inflammatory and anti-nociceptive activities in animal models of intestinal inflammation and inflammatory pain.
Fabisiak A, Fabisiak N, Mokrowiecka A, Malecka-Panas E, Jacenik D, Kordek R, Zielińska M, Kieć-Kononowicz K, Fichna J. Fabisiak A, et al. Among authors: kordek r. Neurogastroenterol Motil. 2021 Mar;33(3):e14003. doi: 10.1111/nmo.14003. Epub 2020 Oct 14. Neurogastroenterol Motil. 2021. PMID: 33058313
Cyclic derivative of morphiceptin Dmt-cyclo-(D-Lys-Phe-D-Pro-Asp)-NH2(P-317), a mixed agonist of MOP and KOP opioid receptors, exerts anti-inflammatory and anti-tumor activity in colitis and colitis-associated colorectal cancer in mice.
Zielińska M, Szymaszkiewicz A, Jacenik D, Schodel L, Sałaga M, Zatorski H, Kordek R, Becker C, Krajewska WM, Fichna J. Zielińska M, et al. Among authors: kordek r. Eur J Pharmacol. 2020 Oct 15;885:173463. doi: 10.1016/j.ejphar.2020.173463. Epub 2020 Aug 22. Eur J Pharmacol. 2020. PMID: 32835668
Anti-inflammatory and antinociceptive action of an orally available nociceptin receptor agonist SCH 221510 in a mouse model of inflammatory bowel diseases.
Sobczak M, Mokrowiecka A, Cygankiewicz AI, Zakrzewski PK, Sałaga M, Storr M, Kordek R, Małecka-Panas E, Krajewska WM, Fichna J. Sobczak M, et al. Among authors: kordek r. J Pharmacol Exp Ther. 2014 Mar;348(3):401-9. doi: 10.1124/jpet.113.209825. Epub 2013 Dec 17. J Pharmacol Exp Ther. 2014. PMID: 24345466
Experimental colitis in mice is attenuated by changes in the levels of endocannabinoid metabolites induced by selective inhibition of fatty acid amide hydrolase (FAAH).
Sałaga M, Mokrowiecka A, Zakrzewski PK, Cygankiewicz A, Leishman E, Sobczak M, Zatorski H, Małecka-Panas E, Kordek R, Storr M, Krajewska WM, Bradshaw HB, Fichna J. Sałaga M, et al. Among authors: kordek r. J Crohns Colitis. 2014 Sep;8(9):998-1009. doi: 10.1016/j.crohns.2014.01.025. Epub 2014 Feb 14. J Crohns Colitis. 2014. PMID: 24530133 Free PMC article.
233 results