Summers MK - Search Results

1

Hyperphosphorylation of CDH1 in Glioblastoma Cancer Stem Cells Attenuates APC/C^CDH1 Activity and Pharmacologic Inhibition of APC/C^CDH1/CDC20 Compromises Viability.

De K, Grubb TM, Zalenski AA, Pfaff KE, Pal D, Majumder S, Summers MK, Venere M. De K, et al. Among authors: summers mk. Mol Cancer Res. 2019 Jul;17(7):1519-1530. doi: 10.1158/1541-7786.MCR-18-1361. Epub 2019 Apr 29. Mol Cancer Res. 2019. PMID: 31036696 Free PMC article.

2

Coordinated regulation of p31(Comet) and Mad2 expression is required for cellular proliferation.

Date DA, Burrows AC, Venere M, Jackson MW, Summers MK. Date DA, et al. Among authors: summers mk. Cell Cycle. 2013 Dec 15;12(24):3824-32. doi: 10.4161/cc.26811. Epub 2013 Oct 15. Cell Cycle. 2013. PMID: 24131926 Free PMC article.

3

The mitotic kinesin KIF11 is a driver of invasion, proliferation, and self-renewal in glioblastoma.

Venere M, Horbinski C, Crish JF, Jin X, Vasanji A, Major J, Burrows AC, Chang C, Prokop J, Wu Q, Sims PA, Canoll P, Summers MK, Rosenfeld SS, Rich JN. Venere M, et al. Among authors: summers mk. Sci Transl Med. 2015 Sep 9;7(304):304ra143. doi: 10.1126/scitranslmed.aac6762. Sci Transl Med. 2015. PMID: 26355032 Free PMC article.

4

Mitotic Vulnerability in Triple-Negative Breast Cancer Associated with LIN9 Is Targetable with BET Inhibitors.

Sahni JM, Gayle SS, Webb BM, Weber-Bonk KL, Seachrist DD, Singh S, Sizemore ST, Restrepo NA, Bebek G, Scacheri PC, Varadan V, Summers MK, Keri RA. Sahni JM, et al. Among authors: summers mk. Cancer Res. 2017 Oct 1;77(19):5395-5408. doi: 10.1158/0008-5472.CAN-17-1571. Epub 2017 Aug 14. Cancer Res. 2017. PMID: 28807940 Free PMC article.

5

USP14 regulates DNA damage repair by targeting RNF168-dependent ubiquitination.

Sharma A, Alswillah T, Singh K, Chatterjee P, Willard B, Venere M, Summers MK, Almasan A. Sharma A, et al. Among authors: summers mk. Autophagy. 2018;14(11):1976-1990. doi: 10.1080/15548627.2018.1496877. Epub 2018 Aug 10. Autophagy. 2018. PMID: 29995557 Free PMC article.

6

LIN9 and NEK2 Are Core Regulators of Mitotic Fidelity That Can Be Therapeutically Targeted to Overcome Taxane Resistance.

Roberts MS, Sahni JM, Schrock MS, Piemonte KM, Weber-Bonk KL, Seachrist DD, Avril S, Anstine LJ, Singh S, Sizemore ST, Varadan V, Summers MK, Keri RA. Roberts MS, et al. Among authors: summers mk. Cancer Res. 2020 Apr 15;80(8):1693-1706. doi: 10.1158/0008-5472.CAN-19-3466. Epub 2020 Feb 13. Cancer Res. 2020. PMID: 32054769 Free PMC article.

7

APC/C ubiquitin ligase: Functions and mechanisms in tumorigenesis.

Schrock MS, Stromberg BR, Scarberry L, Summers MK. Schrock MS, et al. Among authors: summers mk. Semin Cancer Biol. 2020 Dec;67(Pt 2):80-91. doi: 10.1016/j.semcancer.2020.03.001. Epub 2020 Mar 9. Semin Cancer Biol. 2020. PMID: 32165320 Free PMC article. Review.

8

Chk1-mediated phosphorylation of Cdh1 promotes the SCF^βTRCP-dependent degradation of Cdh1 during S-phase and efficient cell-cycle progression.

Pal D, Torres AE, Stromberg BR, Messina AL, Dickson AS, De K, Willard B, Venere M, Summers MK. Pal D, et al. Among authors: summers mk. Cell Death Dis. 2020 Apr 28;11(4):298. doi: 10.1038/s41419-020-2493-1. Cell Death Dis. 2020. PMID: 32345958 Free PMC article.

9

The small molecule drug CBL0137 increases the level of DNA damage and the efficacy of radiotherapy for glioblastoma.

Tallman MM, Zalenski AA, Deighen AM, Schrock MS, Mortach S, Grubb TM, Kastury PS, Huntoon K, Summers MK, Venere M. Tallman MM, et al. Among authors: summers mk. Cancer Lett. 2021 Feb 28;499:232-242. doi: 10.1016/j.canlet.2020.11.027. Epub 2020 Nov 27. Cancer Lett. 2021. PMID: 33253788 Free PMC article.

10

The deubiquitinating enzyme USP37 enhances CHK1 activity to promote the cellular response to replication stress.

Stromberg BR, Singh M, Torres AE, Burrows AC, Pal D, Insinna C, Rhee Y, Dickson AS, Westlake CJ, Summers MK. Stromberg BR, et al. Among authors: summers mk. J Biol Chem. 2021 Oct;297(4):101184. doi: 10.1016/j.jbc.2021.101184. Epub 2021 Sep 10. J Biol Chem. 2021. PMID: 34509474 Free PMC article.

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