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Perioperative systemic therapy and cytoreductive surgery with HIPEC versus upfront cytoreductive surgery with HIPEC alone for isolated resectable colorectal peritoneal metastases: protocol of a multicentre, open-label, parallel-group, phase II-III, randomised, superiority study (CAIRO6).
BMC Cancer. 2019 Apr 25;19(1):390. doi: 10.1186/s12885-019-5545-0.
BMC Cancer. 2019.
PMID: 31023318
Free PMC article.
Clinical Trial.
Adjuvant Systemic Chemotherapy vs Active Surveillance Following Up-front Resection of Isolated Synchronous Colorectal Peritoneal Metastases.
Rovers KP, Bakkers C, van Erning FN, Burger JWA, Nienhuijs SW, Simkens GAAM, Creemers GM, Hemmer PHJ, Punt CJA, Lemmens VEPP, Tanis PJ, de Hingh IHJT.
Rovers KP, et al. Among authors: simkens gaam.
JAMA Oncol. 2020 Aug 1;6(8):e202701. doi: 10.1001/jamaoncol.2020.2701. Epub 2020 Aug 13.
JAMA Oncol. 2020.
PMID: 32672798
Free PMC article.
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Systemic therapy in addition to cytoreduction and hyperthermic intraperitoneal chemotherapy for colorectal peritoneal metastases: recent insights from clinical studies and translational research.
Bakkers C, Simkens GAAM, De Hingh IHJT.
Bakkers C, et al. Among authors: simkens gaam.
J Gastrointest Oncol. 2021 Apr;12(Suppl 1):S206-S213. doi: 10.21037/jgo-20-133.
J Gastrointest Oncol. 2021.
PMID: 33968438
Free PMC article.
Review.
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Acute neurological disorders following intraperitoneal administration of cisplatin.
Simkens GA, Hanse MC, de Hingh IH.
Simkens GA, et al.
Int J Gynaecol Obstet. 2013 Mar;120(3):291. doi: 10.1016/j.ijgo.2012.09.024. Epub 2012 Dec 14.
Int J Gynaecol Obstet. 2013.
PMID: 23245673
Clinical Trial.
No abstract available.
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Perioperative Systemic Therapy Versus Cytoreductive Surgery and HIPEC Alone for Resectable Colorectal Peritoneal Metastases: Patient-Reported Outcomes of a Randomized Phase II Trial.
Bakkers C, Rovers KP, Rijken A, Simkens GAAM, Bonhof CS, Nienhuijs SW, Burger JWA, Creemers GJM, Brandt-Kerkhof ARM, Tuynman JB, Aalbers AGJ, Wiezer MJ, de Reuver PR, van Grevenstein WMU, Hemmer PHJ, Punt CJA, Tanis PJ, Mols F, de Hingh IHJT; Dutch Peritoneal Oncology Group and the Dutch Colorectal Cancer Group.
Bakkers C, et al. Among authors: simkens gaam.
Ann Surg Oncol. 2023 May;30(5):2678-2688. doi: 10.1245/s10434-023-13116-z. Epub 2023 Feb 8.
Ann Surg Oncol. 2023.
PMID: 36754943
Free PMC article.
Clinical Trial.
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