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Phenylpropanoid-based sulfonamide promotes cyclin D1 and cyclin E down-regulation and induces cell cycle arrest at G1/S transition in estrogen positive MCF-7 cell line.
Azevedo-Barbosa H, Ferreira-Silva GÁ, Silva CF, de Souza TB, Dias DF, de Paula ACC, Ionta M, Carvalho DT. Azevedo-Barbosa H, et al. Among authors: ferreira silva ga. Toxicol In Vitro. 2019 Sep;59:150-160. doi: 10.1016/j.tiv.2019.04.023. Epub 2019 Apr 22. Toxicol In Vitro. 2019. PMID: 31022444
Alkaloids derived from flowers of Senna spectabilis, (-)-cassine and (-)-spectaline, have antiproliferative activity on HepG2 cells for inducing cell cycle arrest in G1/S transition through ERK inactivation and downregulation of cyclin D1 expression.
Pereira RM, Ferreira-Silva GÁ, Pivatto M, Santos Lde Á, Bolzani Vda S, Chagas de Paula DA, Oliveira JC, Viegas Júnior C, Ionta M. Pereira RM, et al. Toxicol In Vitro. 2016 Mar;31:86-92. doi: 10.1016/j.tiv.2015.11.018. Epub 2015 Nov 23. Toxicol In Vitro. 2016. PMID: 26616281
[Ru(pipe)(dppb)(bipy)]PF6: A novel ruthenium complex that effectively inhibits ERK activation and cyclin D1 expression in A549 cells.
Ferreira-Silva GA, Ortega MM, Banionis MA, Garavelli GY, Martins FT, Dias JSM, Viegas C Jr, Oliveira JC, Nascimento FBD, Doriguetto AC, Barbosa MIF, Ionta M. Ferreira-Silva GA, et al. Toxicol In Vitro. 2017 Oct;44:382-391. doi: 10.1016/j.tiv.2017.07.019. Epub 2017 Aug 1. Toxicol In Vitro. 2017. PMID: 28774850 Free article.
Design, synthesis and pharmacological evaluation of N-benzyl-piperidinyl-aryl-acylhydrazone derivatives as donepezil hybrids: Discovery of novel multi-target anti-alzheimer prototype drug candidates.
Dias Viegas FP, de Freitas Silva M, Divino da Rocha M, Castelli MR, Riquiel MM, Machado RP, Vaz SM, Simões de Lima LM, Mancini KC, Marques de Oliveira PC, Morais ÉP, Gontijo VS, da Silva FMR, D'Alincourt da Fonseca Peçanha D, Castro NG, Neves GA, Giusti-Paiva A, Vilela FC, Orlandi L, Camps I, Veloso MP, Leomil Coelho LF, Ionta M, Ferreira-Silva GÁ, Pereira RM, Dardenne LE, Guedes IA, de Oliveira Carneiro Junior W, Quaglio Bellozi PM, Pinheiro de Oliveira AC, Ferreira FF, Pruccoli L, Tarozzi A, Viegas C Jr. Dias Viegas FP, et al. Among authors: ferreira silva ga. Eur J Med Chem. 2018 Mar 10;147:48-65. doi: 10.1016/j.ejmech.2018.01.066. Epub 2018 Jan 31. Eur J Med Chem. 2018. PMID: 29421570
15 results