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Narciclasine exerts anti-inflammatory actions by blocking leukocyte-endothelial cell interactions and down-regulation of the endothelial TNF receptor 1.
Stark A, Schwenk R, Wack G, Zuchtriegel G, Hatemler MG, Bräutigam J, Schmidtko A, Reichel CA, Bischoff I, Fürst R. Stark A, et al. Among authors: schmidtko a. FASEB J. 2019 Aug;33(8):8771-8781. doi: 10.1096/fj.201802440R. Epub 2019 Apr 24. FASEB J. 2019. PMID: 31017817
We hypothesized that narciclasine affects the activation of endothelial cells (ECs), a hallmark of inflammatory processes, which is a prerequisite for leukocyte-EC interaction. ...Most importantly, we showed that the observed inhibitory action of narciclasine on TNF …
We hypothesized that narciclasine affects the activation of endothelial cells (ECs), a hallmark of inflammatory processes, which is …
Neuropathic and cAMP-induced pain behavior is ameliorated in mice lacking CNGB1.
Kallenborn-Gerhardt W, Metzner K, Lu R, Petersen J, Kuth MS, Heine S, Drees O, Paul M, Becirovic E, Kennel L, Flauaus C, Gross T, Wack G, Hohmann SW, Nemirovski D, Del Turco D, Biel M, Geisslinger G, Michalakis S, Schmidtko A. Kallenborn-Gerhardt W, et al. Among authors: schmidtko a. Neuropharmacology. 2020 Jul;171:108087. doi: 10.1016/j.neuropharm.2020.108087. Epub 2020 Apr 6. Neuropharmacology. 2020. PMID: 32272140
Rab27a Contributes to the Processing of Inflammatory Pain in Mice.
Gross T, Wack G, Syhr KMJ, Tolmachova T, Seabra MC, Geisslinger G, Niederberger E, Schmidtko A, Kallenborn-Gerhardt W. Gross T, et al. Among authors: schmidtko a. Cells. 2020 Jun 18;9(6):1488. doi: 10.3390/cells9061488. Cells. 2020. PMID: 32570938 Free PMC article.
Boosting Anti-Inflammatory Potency of Zafirlukast by Designed Polypharmacology.
Schierle S, Flauaus C, Heitel P, Willems S, Schmidt J, Kaiser A, Weizel L, Goebel T, Kahnt AS, Geisslinger G, Steinhilber D, Wurglics M, Rovati GE, Schmidtko A, Proschak E, Merk D. Schierle S, et al. Among authors: schmidtko a. J Med Chem. 2018 Jul 12;61(13):5758-5764. doi: 10.1021/acs.jmedchem.8b00458. Epub 2018 Jun 22. J Med Chem. 2018. PMID: 29878767 Free article.
Design, Synthesis, and Structure-Activity Relationship Studies of Dual Inhibitors of Soluble Epoxide Hydrolase and 5-Lipoxygenase.
Hiesinger K, Kramer JS, Beyer S, Eckes T, Brunst S, Flauaus C, Wittmann SK, Weizel L, Kaiser A, Kretschmer SBM, George S, Angioni C, Heering J, Geisslinger G, Schubert-Zsilavecz M, Schmidtko A, Pogoryelov D, Pfeilschifter J, Hofmann B, Steinhilber D, Schwalm S, Proschak E. Hiesinger K, et al. Among authors: schmidtko a. J Med Chem. 2020 Oct 22;63(20):11498-11521. doi: 10.1021/acs.jmedchem.0c00561. Epub 2020 Oct 12. J Med Chem. 2020. PMID: 33044073
69 results