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Novel CHK1 inhibitor MU380 exhibits significant single-agent activity in TP53-mutated chronic lymphocytic leukemia cells.
Boudny M, Zemanova J, Khirsariya P, Borsky M, Verner J, Cerna J, Oltova A, Seda V, Mraz M, Jaros J, Jaskova Z, Spunarova M, Brychtova Y, Soucek K, Drapela S, Kasparkova M, Mayer J, Paruch K, Trbusek M. Boudny M, et al. Among authors: spunarova m. Haematologica. 2019 Dec;104(12):2443-2455. doi: 10.3324/haematol.2018.203430. Epub 2019 Apr 11. Haematologica. 2019. PMID: 30975914 Free PMC article.
Impact of gene mutations and chromosomal aberrations on progression-free survival in chronic lymphocytic leukemia patients treated with front-line chemoimmunotherapy: Clinical practice experience.
Spunarova M, Tom N, Pavlova S, Mraz M, Brychtova Y, Doubek M, Panovska A, Skuhrova Francova H, Brzobohata A, Pospisilova S, Mayer J, Trbusek M. Spunarova M, et al. Leuk Res. 2019 Jun;81:75-81. doi: 10.1016/j.leukres.2019.04.015. Epub 2019 Apr 25. Leuk Res. 2019. PMID: 31054420
Evolution of TP53 abnormalities during CLL disease course is associated with telomere length changes.
Olbertova H, Plevova K, Pavlova S, Malcikova J, Kotaskova J, Stranska K, Spunarova M, Trbusek M, Navrkalova V, Dvorackova B, Tom N, Pal K, Jarosova M, Brychtova Y, Panovska A, Doubek M, Pospisilova S. Olbertova H, et al. Among authors: spunarova m. BMC Cancer. 2022 Feb 3;22(1):137. doi: 10.1186/s12885-022-09221-z. BMC Cancer. 2022. PMID: 35114947 Free PMC article.