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Inhibitors of signal peptide peptidase and subtilisin/kexin-isozyme 1 inhibit Ebola virus glycoprotein-driven cell entry by interfering with activity and cellular localization of endosomal cathepsins.
PLoS One. 2019 Apr 11;14(4):e0214968. doi: 10.1371/journal.pone.0214968. eCollection 2019.
PLoS One. 2019.
PMID: 30973897
Free PMC article.
The Role of Phlebovirus Glycoproteins in Viral Entry, Assembly and Release.
Spiegel M, Plegge T, Pöhlmann S.
Spiegel M, et al. Among authors: plegge t.
Viruses. 2016 Jul 21;8(7):202. doi: 10.3390/v8070202.
Viruses. 2016.
PMID: 27455305
Free PMC article.
Review.
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Evidence that Processing of the Severe Fever with Thrombocytopenia Syndrome Virus Gn/Gc Polyprotein Is Critical for Viral Infectivity and Requires an Internal Gc Signal Peptide.
Plegge T, Hofmann-Winkler H, Spiegel M, Pöhlmann S.
Plegge T, et al.
PLoS One. 2016 Nov 17;11(11):e0166013. doi: 10.1371/journal.pone.0166013. eCollection 2016.
PLoS One. 2016.
PMID: 27855227
Free PMC article.
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Different residues in the SARS-CoV spike protein determine cleavage and activation by the host cell protease TMPRSS2.
Reinke LM, Spiegel M, Plegge T, Hartleib A, Nehlmeier I, Gierer S, Hoffmann M, Hofmann-Winkler H, Winkler M, Pöhlmann S.
Reinke LM, et al. Among authors: plegge t.
PLoS One. 2017 Jun 21;12(6):e0179177. doi: 10.1371/journal.pone.0179177. eCollection 2017.
PLoS One. 2017.
PMID: 28636671
Free PMC article.
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