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Thioredoxin-1 improves the immunometabolic phenotype of antitumor T cells.
Chakraborty P, Chatterjee S, Kesarwani P, Thyagarajan K, Iamsawat S, Dalheim A, Nguyen H, Selvam SP, Nasarre P, Scurti G, Hardiman G, Maulik N, Ball L, Gangaraju V, Rubinstein MP, Klauber-DeMore N, Hill EG, Ogretmen B, Yu XZ, Nishimura MI, Mehrotra S. Chakraborty P, et al. Among authors: ogretmen b. J Biol Chem. 2019 Jun 7;294(23):9198-9212. doi: 10.1074/jbc.RA118.006753. Epub 2019 Apr 10. J Biol Chem. 2019. PMID: 30971427 Free PMC article.
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.
Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B. Senkal CE, et al. Among authors: ogretmen b. J Biol Chem. 2011 Dec 9;286(49):42446-42458. doi: 10.1074/jbc.M111.287383. Epub 2011 Oct 19. J Biol Chem. 2011. PMID: 22013072 Free PMC article.
Off-target function of the Sonic hedgehog inhibitor cyclopamine in mediating apoptosis via nitric oxide-dependent neutral sphingomyelinase 2/ceramide induction.
Meyers-Needham M, Lewis JA, Gencer S, Sentelle RD, Saddoughi SA, Clarke CJ, Hannun YA, Norell H, da Palma TM, Nishimura M, Kraveka JM, Khavandgar Z, Murshed M, Cevik MO, Ogretmen B. Meyers-Needham M, et al. Among authors: ogretmen b. Mol Cancer Ther. 2012 May;11(5):1092-102. doi: 10.1158/1535-7163.MCT-11-0705. Epub 2012 Mar 27. Mol Cancer Ther. 2012. PMID: 22452947 Free PMC article.
Ceramide targets autophagosomes to mitochondria and induces lethal mitophagy.
Sentelle RD, Senkal CE, Jiang W, Ponnusamy S, Gencer S, Selvam SP, Ramshesh VK, Peterson YK, Lemasters JJ, Szulc ZM, Bielawski J, Ogretmen B. Sentelle RD, et al. Among authors: ogretmen b. Nat Chem Biol. 2012 Oct;8(10):831-8. doi: 10.1038/nchembio.1059. Nat Chem Biol. 2012. PMID: 22922758 Free PMC article.
Sphingosine analogue drug FTY720 targets I2PP2A/SET and mediates lung tumour suppression via activation of PP2A-RIPK1-dependent necroptosis.
Saddoughi SA, Gencer S, Peterson YK, Ward KE, Mukhopadhyay A, Oaks J, Bielawski J, Szulc ZM, Thomas RJ, Selvam SP, Senkal CE, Garrett-Mayer E, De Palma RM, Fedarovich D, Liu A, Habib AA, Stahelin RV, Perrotti D, Ogretmen B. Saddoughi SA, et al. Among authors: ogretmen b. EMBO Mol Med. 2013 Jan;5(1):105-21. doi: 10.1002/emmm.201201283. Epub 2012 Nov 25. EMBO Mol Med. 2013. PMID: 23180565 Free PMC article.
140 results