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Bone Marrow Mesenchymal Stromal Cell Treatment in Patients with Osteoarthritis Results in Overall Improvement in Pain and Symptoms and Reduces Synovial Inflammation.
Chahal J, Gómez-Aristizábal A, Shestopaloff K, Bhatt S, Chaboureau A, Fazio A, Chisholm J, Weston A, Chiovitti J, Keating A, Kapoor M, Ogilvie-Harris DJ, Syed KA, Gandhi R, Mahomed NN, Marshall KW, Sussman MS, Naraghi AM, Viswanathan S. Chahal J, et al. Among authors: kapoor m. Stem Cells Transl Med. 2019 Aug;8(8):746-757. doi: 10.1002/sctm.18-0183. Epub 2019 Apr 9. Stem Cells Transl Med. 2019. PMID: 30964245 Free PMC article. Clinical Trial.
PPARγ deficiency results in severe, accelerated osteoarthritis associated with aberrant mTOR signalling in the articular cartilage.
Vasheghani F, Zhang Y, Li YH, Blati M, Fahmi H, Lussier B, Roughley P, Lagares D, Endisha H, Saffar B, Lajeunesse D, Marshall WK, Rampersaud YR, Mahomed NN, Gandhi R, Pelletier JP, Martel-Pelletier J, Kapoor M. Vasheghani F, et al. Among authors: kapoor m. Ann Rheum Dis. 2015 Mar;74(3):569-78. doi: 10.1136/annrheumdis-2014-205743. Epub 2015 Jan 8. Ann Rheum Dis. 2015. PMID: 25573665 Free PMC article.
ADAM10-mediated ephrin-B2 shedding promotes myofibroblast activation and organ fibrosis.
Lagares D, Ghassemi-Kakroodi P, Tremblay C, Santos A, Probst CK, Franklin A, Santos DM, Grasberger P, Ahluwalia N, Montesi SB, Shea BS, Black KE, Knipe R, Blati M, Baron M, Wu B, Fahmi H, Gandhi R, Pardo A, Selman M, Wu J, Pelletier JP, Martel-Pelletier J, Tager AM, Kapoor M. Lagares D, et al. Among authors: kapoor m. Nat Med. 2017 Dec;23(12):1405-1415. doi: 10.1038/nm.4419. Epub 2017 Oct 23. Nat Med. 2017. PMID: 29058717 Free PMC article.
788 results