Lauffenburger DA - Search Results

1

Tissue-Specific Oncogenic Activity of KRAS^A146T.

Poulin EJ, Bera AK, Lu J, Lin YJ, Strasser SD, Paulo JA, Huang TQ, Morales C, Yan W, Cook J, Nowak JA, Brubaker DK, Joughin BA, Johnson CW, DeStefanis RA, Ghazi PC, Gondi S, Wales TE, Iacob RE, Bogdanova L, Gierut JJ, Li Y, Engen JR, Perez-Mancera PA, Braun BS, Gygi SP, Lauffenburger DA, Westover KD, Haigis KM. Poulin EJ, et al. Among authors: lauffenburger da. Cancer Discov. 2019 Jun;9(6):738-755. doi: 10.1158/2159-8290.CD-18-1220. Epub 2019 Apr 5. Cancer Discov. 2019. PMID: 30952657 Free PMC article.

2

An integrated comparative phosphoproteomic and bioinformatic approach reveals a novel class of MPM-2 motifs upregulated in EGFRvIII-expressing glioblastoma cells.

Joughin BA, Naegle KM, Huang PH, Yaffe MB, Lauffenburger DA, White FM. Joughin BA, et al. Among authors: lauffenburger da. Mol Biosyst. 2009 Jan;5(1):59-67. doi: 10.1039/b815075c. Epub 2008 Oct 30. Mol Biosyst. 2009. PMID: 19081932 Free PMC article.

3

RAS mutations affect tumor necrosis factor-induced apoptosis in colon carcinoma cells via ERK-modulatory negative and positive feedback circuits along with non-ERK pathway effects.

Kreeger PK, Mandhana R, Alford SK, Haigis KM, Lauffenburger DA. Kreeger PK, et al. Among authors: lauffenburger da. Cancer Res. 2009 Oct 15;69(20):8191-9. doi: 10.1158/0008-5472.CAN-09-1921. Epub 2009 Sep 29. Cancer Res. 2009. PMID: 19789336 Free PMC article.

4

Integration of multiple signaling pathway activities resolves K-RAS/N-RAS mutation paradox in colon epithelial cell response to inflammatory cytokine stimulation.

Kreeger PK, Wang Y, Haigis KM, Lauffenburger DA. Kreeger PK, et al. Among authors: lauffenburger da. Integr Biol (Camb). 2010 Apr;2(4):202-8. doi: 10.1039/b925935j. Epub 2010 Mar 8. Integr Biol (Camb). 2010. PMID: 20473400 Free PMC article.

5

PTMScout, a Web resource for analysis of high throughput post-translational proteomics studies.

Naegle KM, Gymrek M, Joughin BA, Wagner JP, Welsch RE, Yaffe MB, Lauffenburger DA, White FM. Naegle KM, et al. Among authors: lauffenburger da. Mol Cell Proteomics. 2010 Nov;9(11):2558-70. doi: 10.1074/mcp.M110.001206. Epub 2010 Jul 14. Mol Cell Proteomics. 2010. PMID: 20631208 Free PMC article.

6

In vivo systems analysis identifies spatial and temporal aspects of the modulation of TNF-α-induced apoptosis and proliferation by MAPKs.

Lau KS, Juchheim AM, Cavaliere KR, Philips SR, Lauffenburger DA, Haigis KM. Lau KS, et al. Among authors: lauffenburger da. Sci Signal. 2011 Mar 22;4(165):ra16. doi: 10.1126/scisignal.2001338. Sci Signal. 2011. PMID: 21427409 Free PMC article.

7

BAY61-3606 affects the viability of colon cancer cells in a genotype-directed manner.

Lau KS, Zhang T, Kendall KR, Lauffenburger D, Gray NS, Haigis KM. Lau KS, et al. PLoS One. 2012;7(7):e41343. doi: 10.1371/journal.pone.0041343. Epub 2012 Jul 18. PLoS One. 2012. PMID: 22815993 Free PMC article.

8

Protein kinases display minimal interpositional dependence on substrate sequence: potential implications for the evolution of signalling networks.

Joughin BA, Liu C, Lauffenburger DA, Hogue CW, Yaffe MB. Joughin BA, et al. Among authors: lauffenburger da. Philos Trans R Soc Lond B Biol Sci. 2012 Sep 19;367(1602):2574-83. doi: 10.1098/rstb.2012.0010. Philos Trans R Soc Lond B Biol Sci. 2012. PMID: 22889908 Free PMC article.

9

Multi-scale in vivo systems analysis reveals the influence of immune cells on TNF-α-induced apoptosis in the intestinal epithelium.

Lau KS, Cortez-Retamozo V, Philips SR, Pittet MJ, Lauffenburger DA, Haigis KM. Lau KS, et al. Among authors: lauffenburger da. PLoS Biol. 2012;10(9):e1001393. doi: 10.1371/journal.pbio.1001393. Epub 2012 Sep 25. PLoS Biol. 2012. PMID: 23055830 Free PMC article.

10

Molecular network analysis of phosphotyrosine and lipid metabolism in hepatic PTP1b deletion mice.

Miraldi ER, Sharfi H, Friedline RH, Johnson H, Zhang T, Lau KS, Ko HJ, Curran TG, Haigis KM, Yaffe MB, Bonneau R, Lauffenburger DA, Kahn BB, Kim JK, Neel BG, Saghatelian A, White FM. Miraldi ER, et al. Among authors: lauffenburger da. Integr Biol (Camb). 2013 Jul 24;5(7):940-63. doi: 10.1039/c3ib40013a. Epub 2013 May 20. Integr Biol (Camb). 2013. PMID: 23685806 Free PMC article.

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