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Functional and genetic evidence that the Mal/TIRAP allele variant 180L has been selected by providing protection against septic shock.
Ferwerda B, Alonso S, Banahan K, McCall MB, Giamarellos-Bourboulis EJ, Ramakers BP, Mouktaroudi M, Fain PR, Izagirre N, Syafruddin D, Cristea T, Mockenhaupt FP, Troye-Blomberg M, Kumpf O, Maiga B, Dolo A, Doumbo O, Sundaresan S, Bedu-Addo G, van Crevel R, Hamann L, Oh DY, Schumann RR, Joosten LA, de la Rúa C, Sauerwein R, Drenth JP, Kullberg BJ, van der Ven AJ, Hill AV, Pickkers P, van der Meer JW, O'Neill LA, Netea MG. Ferwerda B, et al. Proc Natl Acad Sci U S A. 2009 Jun 23;106(25):10272-7. doi: 10.1073/pnas.0811273106. Epub 2009 Jun 9. Proc Natl Acad Sci U S A. 2009. PMID: 19509334 Free PMC article.
The ARRIBA concept: adequate resorption of ribavirin.
de Kanter CT, Koning L, Berden FA, Wasmuth JC, Grintjes-Huisman KJ, Becker B, Colbers AP, Roukens MM, Rockstroh JK, Drenth JP, de Knegt RJ, Dofferhoff AS, Burger DM. de Kanter CT, et al. Antivir Ther. 2015;20(5):515-20. doi: 10.3851/IMP2935. Epub 2015 Jan 19. Antivir Ther. 2015. PMID: 25599333 Clinical Trial.
521 results