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Blocking ATM-dependent NF-κB pathway overcomes niche protection and improves chemotherapy response in acute lymphoblastic leukemia.
Chen YL, Tang C, Zhang MY, Huang WL, Xu Y, Sun HY, Yang F, Song LL, Wang H, Mu LL, Li MH, Zheng WW, Miao Y, Ding LX, Li BS, Shen SH, Liu SL, Li H, Zhu ZQ, Chen HW, Tang ZH, Chen J, Hong DL, Chen HZ, Duan CW, Zhou BS. Chen YL, et al. Among authors: yang f. Leukemia. 2019 Oct;33(10):2365-2378. doi: 10.1038/s41375-019-0458-0. Epub 2019 Apr 2. Leukemia. 2019. PMID: 30940905
AICAr suppresses cell proliferation by inducing NTP and dNTP pool imbalances in acute lymphoblastic leukemia cells.
Du L, Yang F, Fang H, Sun H, Chen Y, Xu Y, Li H, Zheng L, Zhou BS. Du L, et al. Among authors: yang f. FASEB J. 2019 Mar;33(3):4525-4537. doi: 10.1096/fj.201801559RR. Epub 2019 Jan 31. FASEB J. 2019. PMID: 30702927
Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role in AICAr-mediated cytotoxic effects on ALL cells, suggesting a potential clinical application of AICAr in future ALL therapy.-Du, L., Ya …
Our data indicate that RNA transcription inhibition and DNA replication stress induced by NTP and dNTP pool imbalances might play a key role …
Adaptive Activation of a Stress Response Pathway Improves Learning and Memory Through Gs and β-Arrestin-1-Regulated Lactate Metabolism.
Dong JH, Wang YJ, Cui M, Wang XJ, Zheng WS, Ma ML, Yang F, He DF, Hu QX, Zhang DL, Ning SL, Liu CH, Wang C, Wang Y, Li XY, Yi F, Lin A, Kahsai AW, Cahill TJ 3rd, Chen ZY, Yu X, Sun JP. Dong JH, et al. Among authors: yang f. Biol Psychiatry. 2017 Apr 15;81(8):654-670. doi: 10.1016/j.biopsych.2016.09.025. Epub 2016 Oct 13. Biol Psychiatry. 2017. PMID: 27916196 Free PMC article.
Switching of the substrate specificity of protein tyrosine phosphatase N12 by cyclin-dependent kinase 2 phosphorylation orchestrating 2 oncogenic pathways.
Li H, Yang D, Ning S, Xu Y, Yang F, Yin R, Feng T, Han S, Guo L, Zhang P, Qu W, Guo R, Song C, Xiao P, Zhou C, Xu Z, Sun JP, Yu X. Li H, et al. Among authors: yang d, yang f. FASEB J. 2018 Jan;32(1):73-82. doi: 10.1096/fj.201700418R. Epub 2017 Aug 24. FASEB J. 2018. PMID: 28842430
The newly identified governing mechanism of the substrate selectivity of a particular phosphatase was previously unappreciated and exemplifies how a phospho-network is precisely controlled in different cellular contexts.-Li, H., Yang, D., Ning, S., Xu, Y., Yang, …
The newly identified governing mechanism of the substrate selectivity of a particular phosphatase was previously unappreciated and exemplifi …
Crystal Structure and Substrate Specificity of PTPN12.
Li H, Yang F, Liu C, Xiao P, Xu Y, Liang Z, Liu C, Wang H, Wang W, Zheng W, Zhang W, Ma X, He D, Song X, Cui F, Xu Z, Yi F, Sun JP, Yu X. Li H, et al. Among authors: yang f. Cell Rep. 2016 May 10;15(6):1345-58. doi: 10.1016/j.celrep.2016.04.016. Epub 2016 Apr 28. Cell Rep. 2016. PMID: 27134172 Free article.
Allosteric mechanisms underlie GPCR signaling to SH3-domain proteins through arrestin.
Yang F, Xiao P, Qu CX, Liu Q, Wang LY, Liu ZX, He QT, Liu C, Xu JY, Li RR, Li MJ, Li Q, Guo XZ, Yang ZY, He DF, Yi F, Ruan K, Shen YM, Yu X, Sun JP, Wang J. Yang F, et al. Among authors: yang zy. Nat Chem Biol. 2018 Sep;14(9):876-886. doi: 10.1038/s41589-018-0115-3. Epub 2018 Aug 17. Nat Chem Biol. 2018. PMID: 30120361
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