Wang J - Search Results

1

Fragment-Based Discovery of an Apolipoprotein E4 (apoE4) Stabilizer.

Petros AM, Korepanova A, Jakob CG, Qiu W, Panchal SC, Wang J, Dietrich JD, Brewer JT, Pohlki F, Kling A, Wilcox K, Lakics V, Bahnassawy L, Reinhardt P, Partha SK, Bodelle PM, Lake M, Charych EI, Stoll VS, Sun C, Mohler EG. Petros AM, et al. Among authors: wang j. J Med Chem. 2019 Apr 25;62(8):4120-4130. doi: 10.1021/acs.jmedchem.9b00178. Epub 2019 Apr 12. J Med Chem. 2019. PMID: 30933499

2

Discovery of a Silicon-Containing Pan-Genotype Hepatitis C Virus NS5A Inhibitor.

Liu B, Gai K, Qin H, Wang J, Liu X, Cao Y, Lu Q, Lu D, Chen D, Shen H, Song W, Mei J, Wang X, Xu H, Zhang Y. Liu B, et al. Among authors: wang x, wang j. J Med Chem. 2020 May 28;63(10):5312-5323. doi: 10.1021/acs.jmedchem.0c00082. Epub 2020 May 7. J Med Chem. 2020. PMID: 32293179

3

Switch type I to type II TRK inhibitors for combating clinical resistance induced by xDFG mutation for cancer therapy.

Xiang S, Wang J, Huang H, Wang Z, Song X, Zhou Y, Jin F, He X, Zhang ZM, Tu Z, Ding K, Zhang Z, Lu X. Xiang S, et al. Among authors: wang j, wang z. Eur J Med Chem. 2023 Jan 5;245(Pt 1):114899. doi: 10.1016/j.ejmech.2022.114899. Epub 2022 Nov 12. Eur J Med Chem. 2023. PMID: 36410169

4

Mtb PKNA/PKNB Dual Inhibition Provides Selectivity Advantages for Inhibitor Design To Minimize Host Kinase Interactions.

Wang T, Bemis G, Hanzelka B, Zuccola H, Wynn M, Moody CS, Green J, Locher C, Liu A, Gao H, Xu Y, Wang S, Wang J, Bennani YL, Thomson JA, Müh U. Wang T, et al. Among authors: wang j, wang s. ACS Med Chem Lett. 2017 Nov 28;8(12):1224-1229. doi: 10.1021/acsmedchemlett.7b00239. eCollection 2017 Dec 14. ACS Med Chem Lett. 2017. PMID: 29259738 Free PMC article.

5

Discovery and optimization of 4-anilinoquinazoline derivatives spanning ATP binding site and allosteric site as effective EGFR-C797S inhibitors.

Dou D, Wang J, Qiao Y, Wumaier G, Sha W, Li W, Mei W, Yang T, Zhang C, He H, Wang C, Chu L, Sun B, Su R, Ma X, Gong M, Xie L, Jiang W, Diao Y, Zhu L, Zhao Z, Chen Z, Xu Y, Li S, Li H. Dou D, et al. Among authors: wang j, wang c. Eur J Med Chem. 2022 Dec 15;244:114856. doi: 10.1016/j.ejmech.2022.114856. Epub 2022 Oct 17. Eur J Med Chem. 2022. PMID: 36279692

6

Discovery of Highly Potent Small-Molecule PD-1/PD-L1 Inhibitors with a Novel Scaffold for Cancer Immunotherapy.

Xu Y, Du H, Guo W, Liu B, Yan W, Zhang C, Qin L, Huang J, Wang H, Wu S, Ren W, Zou Y, Wang J, Zhu Q, Xu Y, Gu H. Xu Y, et al. Among authors: wang h, wang j. J Med Chem. 2024 Mar 14;67(5):4083-4099. doi: 10.1021/acs.jmedchem.3c02362. Epub 2024 Feb 13. J Med Chem. 2024. PMID: 38348878

7

Discovery of LHQ490 as a highly selective fibroblast growth factor receptor 2 (FGFR2) inhibitor.

Li H, Ke R, Zhou Y, Chang S, Wang J, Su C, Wu P, Yang B, Wang Z, Ding K, Ma D. Li H, et al. Among authors: wang j, wang z. Eur J Med Chem. 2024 May 4;272:116473. doi: 10.1016/j.ejmech.2024.116473. Online ahead of print. Eur J Med Chem. 2024. PMID: 38718625

8

New arylpyrazoline-coumarins: Synthesis and anti-inflammatory activity.

Chen LZ, Sun WW, Bo L, Wang JQ, Xiu C, Tang WJ, Shi JB, Zhou HP, Liu XH. Chen LZ, et al. Eur J Med Chem. 2017 Sep 29;138:170-181. doi: 10.1016/j.ejmech.2017.06.044. Epub 2017 Jun 26. Eur J Med Chem. 2017. PMID: 28667873

9

Hiding Payload Inside the IgG Fc Cavity Significantly Enhances the Therapeutic Index of Antibody-Drug Conjugates.

Shi W, Zhang J, Liu L, Li W, Liu Z, Ren A, Wang J, Tang C, Yang Y, Xu D, Huang Q, Wang Y, Luo C, Huang W, Tang F. Shi W, et al. Among authors: wang j, wang y. J Med Chem. 2023 Jan 12;66(1):1011-1026. doi: 10.1021/acs.jmedchem.2c01812. Epub 2022 Dec 30. J Med Chem. 2023. PMID: 36584232

10

Structure-Based Optimization of the Third Generation Type II Macrocycle TRK Inhibitors with Improved Activity against Solvent-Front, xDFG, and Gatekeeper Mutations.

Wang Z, Wang J, Wang Y, Xiang S, Zhou H, Song S, Song X, Tu Z, Zhou Y, Ding K, Zhang ZM, Zhang Z, Lu X. Wang Z, et al. Among authors: wang j, wang y. J Med Chem. 2023 Sep 28;66(18):12950-12965. doi: 10.1021/acs.jmedchem.3c00899. Epub 2023 Sep 7. J Med Chem. 2023. PMID: 37676745

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