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Alpha-synuclein targets GluN2A NMDA receptor subunit causing striatal synaptic dysfunction and visuospatial memory alteration.
Durante V, de Iure A, Loffredo V, Vaikath N, De Risi M, Paciotti S, Quiroga-Varela A, Chiasserini D, Mellone M, Mazzocchetti P, Calabrese V, Campanelli F, Mechelli A, Di Filippo M, Ghiglieri V, Picconi B, El-Agnaf OM, De Leonibus E, Gardoni F, Tozzi A, Calabresi P. Durante V, et al. Among authors: de iure a, de risi m, de leonibus e. Brain. 2019 May 1;142(5):1365-1385. doi: 10.1093/brain/awz065. Brain. 2019. PMID: 30927362 Free article.
Lysosomal dysfunction disrupts presynaptic maintenance and restoration of presynaptic function prevents neurodegeneration in lysosomal storage diseases.
Sambri I, D'Alessio R, Ezhova Y, Giuliano T, Sorrentino NC, Cacace V, De Risi M, Cataldi M, Annunziato L, De Leonibus E, Fraldi A. Sambri I, et al. Among authors: de risi m, de leonibus e. EMBO Mol Med. 2017 Jan;9(1):112-132. doi: 10.15252/emmm.201606965. EMBO Mol Med. 2017. PMID: 27881461 Free PMC article.
The Amyloid Inhibitor CLR01 Relieves Autophagy and Ameliorates Neuropathology in a Severe Lysosomal Storage Disease.
Monaco A, Maffia V, Sorrentino NC, Sambri I, Ezhova Y, Giuliano T, Cacace V, Nusco E, De Risi M, De Leonibus E, Schrader T, Klärner FG, Bitan G, Fraldi A. Monaco A, et al. Among authors: de risi m, de leonibus e. Mol Ther. 2020 Apr 8;28(4):1167-1176. doi: 10.1016/j.ymthe.2020.02.005. Epub 2020 Feb 12. Mol Ther. 2020. PMID: 32087148 Free PMC article.
Mechanisms by which autophagy regulates memory capacity in ageing.
De Risi M, Torromino G, Tufano M, Moriceau S, Pignataro A, Rivagorda M, Carrano N, Middei S, Settembre C, Ammassari-Teule M, Gardoni F, Mele A, Oury F, De Leonibus E. De Risi M, et al. Among authors: de leonibus e. Aging Cell. 2020 Sep;19(9):e13189. doi: 10.1111/acel.13189. Epub 2020 Jul 30. Aging Cell. 2020. PMID: 32729663 Free PMC article.
Orexin-A and endocannabinoids are involved in obesity-associated alteration of hippocampal neurogenesis, plasticity, and episodic memory in mice.
Forte N, Boccella S, Tunisi L, Fernández-Rilo AC, Imperatore R, Iannotti FA, De Risi M, Iannotta M, Piscitelli F, Capasso R, De Girolamo P, De Leonibus E, Maione S, Di Marzo V, Cristino L. Forte N, et al. Among authors: de risi m. Nat Commun. 2021 Oct 21;12(1):6137. doi: 10.1038/s41467-021-26388-4. Nat Commun. 2021. PMID: 34675233 Free PMC article.
Fluoxetine ameliorates mucopolysaccharidosis type IIIA.
Capuozzo A, Montefusco S, Cacace V, Sofia M, Esposito A, Napolitano G, Nusco E, Polishchuk E, Pizzo MT, De Risi M, De Leonibus E, Sorrentino NC, Medina DL. Capuozzo A, et al. Among authors: de risi m. Mol Ther. 2022 Apr 6;30(4):1432-1450. doi: 10.1016/j.ymthe.2022.01.037. Epub 2022 Feb 2. Mol Ther. 2022. PMID: 35121108 Free PMC article.
Thalamo-hippocampal pathway regulates incidental memory capacity in mice.
Torromino G, Loffredo V, Cavezza D, Sonsini G, Esposito F, Crevenna AH, Gioffrè M, De Risi M, Treves A, Griguoli M, De Leonibus E. Torromino G, et al. Among authors: de risi m. Nat Commun. 2022 Jul 20;13(1):4194. doi: 10.1038/s41467-022-31781-8. Nat Commun. 2022. PMID: 35859057 Free PMC article.
46 results