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Spontaneous driving forces give rise to protein-RNA condensates with coexisting phases and complex material properties.
Boeynaems S, Holehouse AS, Weinhardt V, Kovacs D, Van Lindt J, Larabell C, Van Den Bosch L, Das R, Tompa PS, Pappu RV, Gitler AD. Boeynaems S, et al. Among authors: gitler ad. Proc Natl Acad Sci U S A. 2019 Apr 16;116(16):7889-7898. doi: 10.1073/pnas.1821038116. Epub 2019 Mar 29. Proc Natl Acad Sci U S A. 2019. PMID: 30926670 Free PMC article.
Drosophila screen connects nuclear transport genes to DPR pathology in c9ALS/FTD.
Boeynaems S, Bogaert E, Michiels E, Gijselinck I, Sieben A, Jovičić A, De Baets G, Scheveneels W, Steyaert J, Cuijt I, Verstrepen KJ, Callaerts P, Rousseau F, Schymkowitz J, Cruts M, Van Broeckhoven C, Van Damme P, Gitler AD, Robberecht W, Van Den Bosch L. Boeynaems S, et al. Among authors: gitler ad. Sci Rep. 2016 Feb 12;6:20877. doi: 10.1038/srep20877. Sci Rep. 2016. PMID: 26869068 Free PMC article.
Pour Some Sugar on TDP(-43).
Boeynaems S, Gitler AD. Boeynaems S, et al. Among authors: gitler ad. Mol Cell. 2018 Sep 6;71(5):649-651. doi: 10.1016/j.molcel.2018.08.032. Mol Cell. 2018. PMID: 30193092 Free article.
Axons Gonna Ride 'til They Can't No More.
Boeynaems S, Gitler AD. Boeynaems S, et al. Among authors: gitler ad. Neuron. 2019 Oct 23;104(2):179-181. doi: 10.1016/j.neuron.2019.09.029. Neuron. 2019. PMID: 31647889 Free article.
C9orf72-derived arginine-containing dipeptide repeats associate with axonal transport machinery and impede microtubule-based motility.
Fumagalli L, Young FL, Boeynaems S, De Decker M, Mehta AR, Swijsen A, Fazal R, Guo W, Moisse M, Beckers J, Dedeene L, Selvaraj BT, Vandoorne T, Madan V, van Blitterswijk M, Raitcheva D, McCampbell A, Poesen K, Gitler AD, Koch P, Vanden Berghe P, Thal DR, Verfaillie C, Chandran S, Van Den Bosch L, Bullock SL, Van Damme P. Fumagalli L, et al. Among authors: gitler ad. Sci Adv. 2021 Apr 9;7(15):eabg3013. doi: 10.1126/sciadv.abg3013. Print 2021 Apr. Sci Adv. 2021. PMID: 33837088 Free PMC article.
A prion-like protein regulator of seed germination undergoes hydration-dependent phase separation.
Dorone Y, Boeynaems S, Flores E, Jin B, Hateley S, Bossi F, Lazarus E, Pennington JG, Michiels E, De Decker M, Vints K, Baatsen P, Bassel GW, Otegui MS, Holehouse AS, Exposito-Alonso M, Sukenik S, Gitler AD, Rhee SY. Dorone Y, et al. Among authors: gitler ad. Cell. 2021 Aug 5;184(16):4284-4298.e27. doi: 10.1016/j.cell.2021.06.009. Epub 2021 Jul 6. Cell. 2021. PMID: 34233164 Free PMC article.
You come at the misfolded proteins, you best not miss.
Boeynaems S, Gitler AD. Boeynaems S, et al. Among authors: gitler ad. Trends Biochem Sci. 2022 Jan;47(1):1-2. doi: 10.1016/j.tibs.2021.10.001. Epub 2021 Oct 12. Trends Biochem Sci. 2022. PMID: 34654581
168 results