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A farnesyltransferase inhibitor activates lysosomes and reduces tau pathology in mice with tauopathy.
Hernandez I, Luna G, Rauch JN, Reis SA, Giroux M, Karch CM, Boctor D, Sibih YE, Storm NJ, Diaz A, Kaushik S, Zekanowski C, Kang AA, Hinman CR, Cerovac V, Guzman E, Zhou H, Haggarty SJ, Goate AM, Fisher SK, Cuervo AM, Kosik KS. Hernandez I, et al. Among authors: cuervo am. Sci Transl Med. 2019 Mar 27;11(485):eaat3005. doi: 10.1126/scitranslmed.aat3005. Sci Transl Med. 2019. PMID: 30918111 Free PMC article.
Consequences of the selective blockage of chaperone-mediated autophagy.
Massey AC, Kaushik S, Sovak G, Kiffin R, Cuervo AM. Massey AC, et al. Among authors: cuervo am. Proc Natl Acad Sci U S A. 2006 Apr 11;103(15):5805-10. doi: 10.1073/pnas.0507436103. Epub 2006 Apr 3. Proc Natl Acad Sci U S A. 2006. PMID: 16585521 Free PMC article.
Lysosomal chat maintains the balance.
Massey AC, Kaushik S, Cuervo AM. Massey AC, et al. Among authors: cuervo am. Autophagy. 2006 Oct-Dec;2(4):325-7. doi: 10.4161/auto.3090. Epub 2006 Oct 13. Autophagy. 2006. PMID: 16874078 Review.
Dopamine-modified alpha-synuclein blocks chaperone-mediated autophagy.
Martinez-Vicente M, Talloczy Z, Kaushik S, Massey AC, Mazzulli J, Mosharov EV, Hodara R, Fredenburg R, Wu DC, Follenzi A, Dauer W, Przedborski S, Ischiropoulos H, Lansbury PT, Sulzer D, Cuervo AM. Martinez-Vicente M, et al. Among authors: cuervo am. J Clin Invest. 2008 Feb;118(2):777-88. doi: 10.1172/JCI32806. J Clin Invest. 2008. PMID: 18172548 Free PMC article.
293 results