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Dual Pharmacophores Explored via Structure-Activity Relationship (SAR) Matrix: Insights into Potent, Bifunctional Opioid Ligand Design.
J Med Chem. 2019 Apr 25;62(8):4193-4203. doi: 10.1021/acs.jmedchem.9b00378. Epub 2019 Apr 9.
J Med Chem. 2019.
PMID: 30916966
Free PMC article.
In vivo effects of μ-opioid receptor agonist/δ-opioid receptor antagonist peptidomimetics following acute and repeated administration.
Anand JP, Kochan KE, Nastase AF, Montgomery D, Griggs NW, Traynor JR, Mosberg HI, Jutkiewicz EM.
Anand JP, et al. Among authors: nastase af.
Br J Pharmacol. 2018 Jun;175(11):2013-2027. doi: 10.1111/bph.14148. Epub 2018 Apr 24.
Br J Pharmacol. 2018.
PMID: 29352503
Free PMC article.
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Synthesis and Pharmacological Evaluation of Novel C-8 Substituted Tetrahydroquinolines as Balanced-Affinity Mu/Delta Opioid Ligands for the Treatment of Pain.
Nastase AF, Griggs NW, Anand JP, Fernandez TJ, Harland AA, Trask TJ, Jutkiewicz EM, Traynor JR, Mosberg HI.
Nastase AF, et al.
ACS Chem Neurosci. 2018 Jul 18;9(7):1840-1848. doi: 10.1021/acschemneuro.8b00139. Epub 2018 May 2.
ACS Chem Neurosci. 2018.
PMID: 29677442
Free PMC article.
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Simple structure-based approach for predicting the activity of inhibitors of beta-secretase (BACE1) associated with Alzheimer's disease.
Nastase AF, Boyd DB.
Nastase AF, et al.
J Chem Inf Model. 2012 Dec 21;52(12):3302-7. doi: 10.1021/ci300331d. Epub 2012 Dec 3.
J Chem Inf Model. 2012.
PMID: 23198745
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