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Zeptomole per milliliter detection and quantification of edema factor in plasma by LC-MS/MS yields insights into toxemia and the progression of inhalation anthrax.
Lins RC, Boyer AE, Kuklenyik Z, Woolfitt AR, Goldstein J, Hoffmaster AR, Gallegos-Candela M, Leysath CE, Chen Z, Brumlow JO, Quinn CP, Bagarozzi DA Jr, Leppla SH, Barr JR. Lins RC, et al. Among authors: chen z. Anal Bioanal Chem. 2019 May;411(12):2493-2509. doi: 10.1007/s00216-019-01730-4. Epub 2019 Mar 26. Anal Bioanal Chem. 2019. PMID: 30911800 Free PMC article.
Delayed treatment with W1-mAb, a chimpanzee-derived monoclonal antibody against protective antigen, reduces mortality from challenges with anthrax edema or lethal toxin in rats and with anthrax spores in mice.
Altaweel L, Chen Z, Moayeri M, Cui X, Li Y, Su J, Fitz Y, Johnson S, Leppla SH, Purcell R, Eichacker PQ. Altaweel L, et al. Among authors: chen z. Crit Care Med. 2011 Jun;39(6):1439-47. doi: 10.1097/CCM.0b013e3182120691. Crit Care Med. 2011. PMID: 21336113 Free PMC article.
Mouse monoclonal antibodies to anthrax edema factor protect against infection.
Leysath CE, Chen KH, Moayeri M, Crown D, Fattah R, Chen Z, Das SR, Purcell RH, Leppla SH. Leysath CE, et al. Among authors: chen z, chen kh. Infect Immun. 2011 Nov;79(11):4609-16. doi: 10.1128/IAI.05314-11. Epub 2011 Sep 12. Infect Immun. 2011. PMID: 21911463 Free PMC article.
Monoclonal antibody therapies against anthrax.
Chen Z, Moayeri M, Purcell R. Chen Z, et al. Toxins (Basel). 2011 Aug;3(8):1004-19. doi: 10.3390/toxins3081004. Epub 2011 Aug 15. Toxins (Basel). 2011. PMID: 22069754 Free PMC article. Review.
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