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Intestinal epithelial MyD88 is a sensor switching host metabolism towards obesity according to nutritional status.
Everard A, Geurts L, Caesar R, Van Hul M, Matamoros S, Duparc T, Denis RG, Cochez P, Pierard F, Castel J, Bindels LB, Plovier H, Robine S, Muccioli GG, Renauld JC, Dumoutier L, Delzenne NM, Luquet S, Bäckhed F, Cani PD. Everard A, et al. Among authors: caesar r. Nat Commun. 2014 Dec 5;5:5648. doi: 10.1038/ncomms6648. Nat Commun. 2014. PMID: 25476696 Free PMC article.
Microbiota-induced obesity requires farnesoid X receptor.
Parséus A, Sommer N, Sommer F, Caesar R, Molinaro A, Ståhlman M, Greiner TU, Perkins R, Bäckhed F. Parséus A, et al. Among authors: caesar r. Gut. 2017 Mar;66(3):429-437. doi: 10.1136/gutjnl-2015-310283. Epub 2016 Jan 6. Gut. 2017. PMID: 26740296 Free PMC article.
Metformin alters the gut microbiome of individuals with treatment-naive type 2 diabetes, contributing to the therapeutic effects of the drug.
Wu H, Esteve E, Tremaroli V, Khan MT, Caesar R, Mannerås-Holm L, Ståhlman M, Olsson LM, Serino M, Planas-Fèlix M, Xifra G, Mercader JM, Torrents D, Burcelin R, Ricart W, Perkins R, Fernàndez-Real JM, Bäckhed F. Wu H, et al. Among authors: caesar r. Nat Med. 2017 Jul;23(7):850-858. doi: 10.1038/nm.4345. Epub 2017 May 22. Nat Med. 2017. PMID: 28530702 Clinical Trial.
120 results