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Machine learning-powered antibiotics phenotypic drug discovery.
Zoffmann S, Vercruysse M, Benmansour F, Maunz A, Wolf L, Blum Marti R, Heckel T, Ding H, Truong HH, Prummer M, Schmucki R, Mason CS, Bradley K, Jacob AI, Lerner C, Araujo Del Rosario A, Burcin M, Amrein KE, Prunotto M. Zoffmann S, et al. Among authors: bradley k. Sci Rep. 2019 Mar 21;9(1):5013. doi: 10.1038/s41598-019-39387-9. Sci Rep. 2019. PMID: 30899034 Free PMC article.
Discovery of Pyrido[2,3-b]indole Derivatives with Gram-Negative Activity Targeting Both DNA Gyrase and Topoisomerase IV.
Hu Y, Shi H, Zhou M, Ren Q, Zhu W, Zhang W, Zhang Z, Zhou C, Liu Y, Ding X, Shen HC, Yan SF, Dey F, Wu W, Zhai G, Zhou Z, Xu Z, Ji Y, Lv H, Jiang T, Wang W, Xu Y, Vercruysse M, Yao X, Mao Y, Yu X, Bradley K, Tan X. Hu Y, et al. Among authors: bradley k. J Med Chem. 2020 Sep 10;63(17):9623-9649. doi: 10.1021/acs.jmedchem.0c00768. Epub 2020 Aug 24. J Med Chem. 2020. PMID: 32787097
Selective inhibitor of endosomal trafficking pathways exploited by multiple toxins and viruses.
Gillespie EJ, Ho CL, Balaji K, Clemens DL, Deng G, Wang YE, Elsaesser HJ, Tamilselvam B, Gargi A, Dixon SD, France B, Chamberlain BT, Blanke SR, Cheng G, de la Torre JC, Brooks DG, Jung ME, Colicelli J, Damoiseaux R, Bradley KA. Gillespie EJ, et al. Among authors: bradley ka. Proc Natl Acad Sci U S A. 2013 Dec 10;110(50):E4904-12. doi: 10.1073/pnas.1302334110. Epub 2013 Nov 4. Proc Natl Acad Sci U S A. 2013. PMID: 24191014 Free PMC article.
1,082 results