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The garlic compound ajoene covalently binds vimentin, disrupts the vimentin network and exerts anti-metastatic activity in cancer cells.
BMC Cancer. 2019 Mar 20;19(1):248. doi: 10.1186/s12885-019-5388-8.
BMC Cancer. 2019.
PMID: 30894168
Free PMC article.
Structure-activity studies on the anti-proliferation activity of ajoene analogues in WHCO1 oesophageal cancer cells.
Kaschula CH, Hunter R, Stellenboom N, Caira MR, Winks S, Ogunleye T, Richards P, Cotton J, Zilbeyaz K, Wang Y, Siyo V, Ngarande E, Parker MI.
Kaschula CH, et al. Among authors: ngarande e.
Eur J Med Chem. 2012 Apr;50:236-54. doi: 10.1016/j.ejmech.2012.01.058. Epub 2012 Feb 11.
Eur J Med Chem. 2012.
PMID: 22381354
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The garlic compound ajoene targets protein folding in the endoplasmic reticulum of cancer cells.
Kaschula CH, Hunter R, Cotton J, Tuveri R, Ngarande E, Dzobo K, Schäfer G, Siyo V, Lang D, Kusza DA, Davies B, Katz AA, Parker MI.
Kaschula CH, et al. Among authors: ngarande e.
Mol Carcinog. 2016 Aug;55(8):1213-28. doi: 10.1002/mc.22364. Epub 2015 Jul 24.
Mol Carcinog. 2016.
PMID: 26207910
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Overexpression of Kpnβ1 and Kpnα2 importin proteins in cancer derives from deregulated E2F activity.
van der Watt PJ, Ngarande E, Leaner VD.
van der Watt PJ, et al. Among authors: ngarande e.
PLoS One. 2011;6(11):e27723. doi: 10.1371/journal.pone.0027723. Epub 2011 Nov 18.
PLoS One. 2011.
PMID: 22125623
Free PMC article.
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Prevalence of Myocardial Injury and Myocardial Infarction in Patients with a Hypertensive Emergency: A Systematic Review.
Talle MA, Ngarande E, Doubell AF, Herbst PG.
Talle MA, et al. Among authors: ngarande e.
Diagnostics (Basel). 2022 Dec 26;13(1):60. doi: 10.3390/diagnostics13010060.
Diagnostics (Basel). 2022.
PMID: 36611351
Free PMC article.
Review.
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Modified fibrin hydrogel for sustained delivery of RNAi lipopolyplexes in skeletal muscle.
Ngarande E, Doubell E, Tamgue O, Mano M, Human P, Giacca M, Davies NH.
Ngarande E, et al.
Regen Biomater. 2022 Dec 13;10:rbac101. doi: 10.1093/rb/rbac101. eCollection 2023.
Regen Biomater. 2022.
PMID: 36726610
Free PMC article.
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Cardiac Complications of Hypertensive Emergency: Classification, Diagnosis and Management Challenges.
Talle MA, Ngarande E, Doubell AF, Herbst PG.
Talle MA, et al. Among authors: ngarande e.
J Cardiovasc Dev Dis. 2022 Aug 17;9(8):276. doi: 10.3390/jcdd9080276.
J Cardiovasc Dev Dis. 2022.
PMID: 36005440
Free PMC article.
Review.
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The incidence and outcomes of high-risk acute coronary syndromes in Western Cape Province, South Africa: A prospective cohort study.
Cilliers JCD, Joubert L, Beyers B, Ngarande E, Herbst P, Doubell A, Pecoraro A.
Cilliers JCD, et al. Among authors: ngarande e.
S Afr Med J. 2023 Apr 12;113(5):25-29. doi: 10.7196/SAMJ.2023.v113i5.16764.
S Afr Med J. 2023.
PMID: 37170600
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