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Strain-induced mechanotransduction through primary cilia, extracellular ATP, purinergic calcium signaling, and ERK1/2 transactivates CITED2 and downregulates MMP-1 and MMP-13 gene expression in chondrocytes.
He Z, Leong DJ, Zhuo Z, Majeska RJ, Cardoso L, Spray DC, Goldring MB, Cobelli NJ, Sun HB. He Z, et al. Among authors: majeska rj. Osteoarthritis Cartilage. 2016 May;24(5):892-901. doi: 10.1016/j.joca.2015.11.015. Epub 2015 Dec 12. Osteoarthritis Cartilage. 2016. PMID: 26687824 Free article.
Physiological loading of joints prevents cartilage degradation through CITED2.
Leong DJ, Li YH, Gu XI, Sun L, Zhou Z, Nasser P, Laudier DM, Iqbal J, Majeska RJ, Schaffler MB, Goldring MB, Cardoso L, Zaidi M, Sun HB. Leong DJ, et al. Among authors: majeska rj. FASEB J. 2011 Jan;25(1):182-91. doi: 10.1096/fj.10-164277. Epub 2010 Sep 8. FASEB J. 2011. PMID: 20826544 Free PMC article.
Osteocyte calcium signals encode strain magnitude and loading frequency in vivo.
Lewis KJ, Frikha-Benayed D, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Lewis KJ, et al. Among authors: majeska rj. Proc Natl Acad Sci U S A. 2017 Oct 31;114(44):11775-11780. doi: 10.1073/pnas.1707863114. Epub 2017 Oct 19. Proc Natl Acad Sci U S A. 2017. PMID: 29078317 Free PMC article.
Estrogen depletion on In vivo osteocyte calcium signaling responses to mechanical loading.
Lewis KJ, Cabahug-Zuckerman P, Boorman-Padgett JF, Basta-Pljakic J, Louie J, Stephen S, Spray DC, Thi MM, Seref-Ferlengez Z, Majeska RJ, Weinbaum S, Schaffler MB. Lewis KJ, et al. Among authors: majeska rj. Bone. 2021 Nov;152:116072. doi: 10.1016/j.bone.2021.116072. Epub 2021 Jun 24. Bone. 2021. PMID: 34171514 Free PMC article.
84 results