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A DNA vaccine coding for the Brucella outer membrane protein 31 confers protection against B. melitensis and B. ovis infection by eliciting a specific cytotoxic response.
Cassataro J, Velikovsky CA, de la Barrera S, Estein SM, Bruno L, Bowden R, Pasquevich KA, Fossati CA, Giambartolomei GH. Cassataro J, et al. Among authors: estein sm. Infect Immun. 2005 Oct;73(10):6537-46. doi: 10.1128/IAI.73.10.6537-6546.2005. Infect Immun. 2005. PMID: 16177328 Free PMC article.
Improved immunogenicity of a vaccination regimen combining a DNA vaccine encoding Brucella melitensis outer membrane protein 31 (Omp31) and recombinant Omp31 boosting.
Cassataro J, Velikovsky CA, Bruno L, Estein SM, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH. Cassataro J, et al. Among authors: estein sm. Clin Vaccine Immunol. 2007 Jul;14(7):869-74. doi: 10.1128/CVI.00472-06. Epub 2007 Apr 11. Clin Vaccine Immunol. 2007. PMID: 17428946 Free PMC article.
A recombinant subunit vaccine based on the insertion of 27 amino acids from Omp31 to the N-terminus of BLS induced a similar degree of protection against B. ovis than Rev.1 vaccination.
Cassataro J, Pasquevich KA, Estein SM, Laplagne DA, Velikovsky CA, de la Barrera S, Bowden R, Fossati CA, Giambartolomei GH, Goldbaum FA. Cassataro J, et al. Among authors: estein sm. Vaccine. 2007 May 30;25(22):4437-46. doi: 10.1016/j.vaccine.2007.03.028. Epub 2007 Apr 2. Vaccine. 2007. PMID: 17442465
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