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In vitro screening of cytochrome P450 induction potential.
Pelkonen O, Hukkanen J, Honkakoski P, Hakkola J, Viitala P, Raunio H. Pelkonen O, et al. Among authors: hakkola j. Ernst Schering Res Found Workshop. 2002;(37):105-37. doi: 10.1007/978-3-662-04383-7_6. Ernst Schering Res Found Workshop. 2002. PMID: 11975192 Review. No abstract available.
Energy-sensing factors coactivator peroxisome proliferator-activated receptor γ coactivator 1-α (PGC-1α) and AMP-activated protein kinase control expression of inflammatory mediators in liver: induction of interleukin 1 receptor antagonist.
Buler M, Aatsinki SM, Skoumal R, Komka Z, Tóth M, Kerkelä R, Georgiadi A, Kersten S, Hakkola J. Buler M, et al. Among authors: hakkola j. J Biol Chem. 2012 Jan 13;287(3):1847-60. doi: 10.1074/jbc.M111.302356. Epub 2011 Nov 23. J Biol Chem. 2012. PMID: 22117073 Free PMC article.
Pregnane X receptor agonists impair postprandial glucose tolerance.
Rysä J, Buler M, Savolainen MJ, Ruskoaho H, Hakkola J, Hukkanen J. Rysä J, et al. Among authors: hakkola j. Clin Pharmacol Ther. 2013 Jun;93(6):556-63. doi: 10.1038/clpt.2013.48. Epub 2013 Mar 5. Clin Pharmacol Ther. 2013. PMID: 23588309 Clinical Trial.
SIRT5 is under the control of PGC-1α and AMPK and is involved in regulation of mitochondrial energy metabolism.
Buler M, Aatsinki SM, Izzi V, Uusimaa J, Hakkola J. Buler M, et al. Among authors: hakkola j. FASEB J. 2014 Jul;28(7):3225-37. doi: 10.1096/fj.13-245241. Epub 2014 Mar 31. FASEB J. 2014. PMID: 24687991
Moreover, SIRT5 levels are regulated by PGC-1alpha and AMPK, which have opposite effects on its expression.-Buler, M., Aatsinki, S.-M., Izzi, V., Uusimaa, J., Hakkola, J. SIRT5 is under the control of PGC-1alpha and AMPK and is involved in regulation of mitoc …
Moreover, SIRT5 levels are regulated by PGC-1alpha and AMPK, which have opposite effects on its expression.-Buler, M., Aatsinki, S.-M., Izzi …
Who watches the watchmen? Regulation of the expression and activity of sirtuins.
Buler M, Andersson U, Hakkola J. Buler M, et al. Among authors: hakkola j. FASEB J. 2016 Dec;30(12):3942-3960. doi: 10.1096/fj.201600410RR. Epub 2016 Sep 2. FASEB J. 2016. PMID: 27591175 Review.
We also discuss the consequences of this regulation on sirtuin function and cellular physiology.-Buler, M., Andersson, U., Hakkola, J. Who watches the watchmen? Regulation of the expression and activity of sirtuins....
We also discuss the consequences of this regulation on sirtuin function and cellular physiology.-Buler, M., Andersson, U., Hakkola, …
90 results