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Page 1
Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.
Weng T, Ko J, Masamha CP, Xia Z, Xiang Y, Chen NY, Molina JG, Collum S, Mertens TC, Luo F, Philip K, Davies J, Huang J, Wilson C, Thandavarayan RA, Bruckner BA, Jyothula SS, Volcik KA, Li L, Han L, Li W, Assassi S, Karmouty-Quintana H, Wagner EJ, Blackburn MR. Weng T, et al. Among authors: philip k. J Clin Invest. 2019 Feb 28;129(5):1984-1999. doi: 10.1172/JCI122106. Print 2019 May 1. J Clin Invest. 2019. PMID: 30830875 Free PMC article.
Blockade of IL-6 Trans signaling attenuates pulmonary fibrosis.
Le TT, Karmouty-Quintana H, Melicoff E, Le TT, Weng T, Chen NY, Pedroza M, Zhou Y, Davies J, Philip K, Molina J, Luo F, George AT, Garcia-Morales LJ, Bunge RR, Bruckner BA, Loebe M, Seethamraju H, Agarwal SK, Blackburn MR. Le TT, et al. Among authors: philip k. J Immunol. 2014 Oct 1;193(7):3755-68. doi: 10.4049/jimmunol.1302470. Epub 2014 Aug 29. J Immunol. 2014. PMID: 25172494 Free PMC article. Clinical Trial.
Deletion of ADORA2B from myeloid cells dampens lung fibrosis and pulmonary hypertension.
Karmouty-Quintana H, Philip K, Acero LF, Chen NY, Weng T, Molina JG, Luo F, Davies J, Le NB, Bunge I, Volcik KA, Le TT, Johnston RA, Xia Y, Eltzschig HK, Blackburn MR. Karmouty-Quintana H, et al. Among authors: philip k. FASEB J. 2015 Jan;29(1):50-60. doi: 10.1096/fj.14-260182. Epub 2014 Oct 15. FASEB J. 2015. PMID: 25318478 Free PMC article.
Altered Hypoxic-Adenosine Axis and Metabolism in Group III Pulmonary Hypertension.
Garcia-Morales LJ, Chen NY, Weng T, Luo F, Davies J, Philip K, Volcik KA, Melicoff E, Amione-Guerra J, Bunge RR, Bruckner BA, Loebe M, Eltzschig HK, Pandit LM, Blackburn MR, Karmouty-Quintana H. Garcia-Morales LJ, et al. Among authors: philip k. Am J Respir Cell Mol Biol. 2016 Apr;54(4):574-83. doi: 10.1165/rcmb.2015-0145OC. Am J Respir Cell Mol Biol. 2016. PMID: 26414702 Free PMC article.
Macrophage bone morphogenic protein receptor 2 depletion in idiopathic pulmonary fibrosis and Group III pulmonary hypertension.
Chen NY, D Collum S, Luo F, Weng T, Le TT, M Hernandez A, Philip K, Molina JG, Garcia-Morales LJ, Cao Y, Ko TC, Amione-Guerra J, Al-Jabbari O, Bunge RR, Youker K, Bruckner BA, Hamid R, Davies J, Sinha N, Karmouty-Quintana H. Chen NY, et al. Among authors: philip k. Am J Physiol Lung Cell Mol Physiol. 2016 Aug 1;311(2):L238-54. doi: 10.1152/ajplung.00142.2016. Epub 2016 Jun 17. Am J Physiol Lung Cell Mol Physiol. 2016. PMID: 27317687 Free PMC article.
HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis.
Philip K, Mills TW, Davies J, Chen NY, Karmouty-Quintana H, Luo F, Molina JG, Amione-Guerra J, Sinha N, Guha A, Eltzschig HK, Blackburn MR. Philip K, et al. FASEB J. 2017 Nov;31(11):4745-4758. doi: 10.1096/fj.201700219R. Epub 2017 Jul 12. FASEB J. 2017. PMID: 28701304 Free PMC article.
These studies support a potential role for HIF1A or ADORA2B antagonists in the treatment of IPF.-Philip, K., Mills, T. W., Davies, J., Chen, N.-Y., Karmouty-Quintana, H., Luo, F., Molina, J. G., Amione-Guerra, J., Sinha, N., Guha, A., Eltzschig, H. K., Blackb …
These studies support a potential role for HIF1A or ADORA2B antagonists in the treatment of IPF.-Philip, K., Mills, T. W., Dav …
The Antifibrotic Effect of A2B Adenosine Receptor Antagonism in a Mouse Model of Dermal Fibrosis.
Karmouty-Quintana H, Molina JG, Philip K, Bellocchi C, Gudenkauf B, Wu M, Chen NY, Collum SD, Ko J, Agarwal SK, Assassi S, Zhong H, Blackburn MR, Weng T. Karmouty-Quintana H, et al. Among authors: philip k. Arthritis Rheumatol. 2018 Oct;70(10):1673-1684. doi: 10.1002/art.40554. Epub 2018 Aug 6. Arthritis Rheumatol. 2018. PMID: 29771006 Free PMC article.
Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.
Collum SD, Molina JG, Hanmandlu A, Bi W, Pedroza M, Mertens TCJ, Wareing N, Wei W, Wilson C, Sun W, Rajadas J, Bollyky PL, Philip KM, Ren D, Thandavarayan RA, Bruckner BA, Xia Y, Blackburn MR, Karmouty-Quintana H. Collum SD, et al. Dis Model Mech. 2019 May 15;12(5):dmm038711. doi: 10.1242/dmm.038711. Dis Model Mech. 2019. PMID: 31036697 Free PMC article.
190 results