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MYC inhibits the clock and supports proliferation.
Shostak A, Diernfellner A, Brunner M. Shostak A, et al. Cell Cycle. 2016 Dec 16;15(24):3323-3324. doi: 10.1080/15384101.2016.1224760. Epub 2016 Sep 7. Cell Cycle. 2016. PMID: 27602886 Free PMC article. No abstract available.
The circadian cryptochrome, CRY1, is a pro-tumorigenic factor that rhythmically modulates DNA repair.
Shafi AA, McNair CM, McCann JJ, Alshalalfa M, Shostak A, Severson TM, Zhu Y, Bergman A, Gordon N, Mandigo AC, Chand SN, Gallagher P, Dylgjeri E, Laufer TS, Vasilevskaya IA, Schiewer MJ, Brunner M, Feng FY, Zwart W, Knudsen KE. Shafi AA, et al. Among authors: shostak a. Nat Commun. 2021 Jan 15;12(1):401. doi: 10.1038/s41467-020-20513-5. Nat Commun. 2021. PMID: 33452241 Free PMC article.
Thiolutin is a zinc chelator that inhibits the Rpn11 and other JAMM metalloproteases.
Lauinger L, Li J, Shostak A, Cemel IA, Ha N, Zhang Y, Merkl PE, Obermeyer S, Stankovic-Valentin N, Schafmeier T, Wever WJ, Bowers AA, Carter KP, Palmer AE, Tschochner H, Melchior F, Deshaies RJ, Brunner M, Diernfellner A. Lauinger L, et al. Among authors: shostak a. Nat Chem Biol. 2017 Jul;13(7):709-714. doi: 10.1038/nchembio.2370. Epub 2017 May 1. Nat Chem Biol. 2017. PMID: 28459440 Free PMC article.
121 results