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Atherogenic LOX-1 signaling is controlled by SPPL2-mediated intramembrane proteolysis.
Mentrup T, Theodorou K, Cabrera-Cabrera F, Helbig AO, Happ K, Gijbels M, Gradtke AC, Rabe B, Fukumori A, Steiner H, Tholey A, Fluhrer R, Donners M, Schröder B. Mentrup T, et al. Among authors: tholey a. J Exp Med. 2019 Apr 1;216(4):807-830. doi: 10.1084/jem.20171438. Epub 2019 Feb 28. J Exp Med. 2019. PMID: 30819724 Free PMC article.
Cancer-associated mutations in the canonical cleavage site do not influence CD99 shedding by the metalloprotease meprin β but alter cell migration in vitro.
Bedau T, Schumacher N, Peters F, Prox J, Arnold P, Koudelka T, Helm O, Schmidt F, Rabe B, Jentzsch M, Rosenstiel P, Sebens S, Tholey A, Rose-John S, Becker-Pauly C. Bedau T, et al. Among authors: tholey a. Oncotarget. 2017 Jul 4;8(33):54873-54888. doi: 10.18632/oncotarget.18966. eCollection 2017 Aug 15. Oncotarget. 2017. PMID: 28903388 Free PMC article.
Degradome of soluble ADAM10 and ADAM17 metalloproteases.
Scharfenberg F, Helbig A, Sammel M, Benzel J, Schlomann U, Peters F, Wichert R, Bettendorff M, Schmidt-Arras D, Rose-John S, Moali C, Lichtenthaler SF, Pietrzik CU, Bartsch JW, Tholey A, Becker-Pauly C. Scharfenberg F, et al. Among authors: tholey a. Cell Mol Life Sci. 2020 Jan;77(2):331-350. doi: 10.1007/s00018-019-03184-4. Epub 2019 Jun 17. Cell Mol Life Sci. 2020. PMID: 31209506 Free PMC article.
Meprin β induces activities of A disintegrin and metalloproteinases 9, 10, and 17 by specific prodomain cleavage.
Wichert R, Scharfenberg F, Colmorgen C, Koudelka T, Schwarz J, Wetzel S, Potempa B, Potempa J, Bartsch JW, Sagi I, Tholey A, Saftig P, Rose-John S, Becker-Pauly C. Wichert R, et al. Among authors: tholey a. FASEB J. 2019 Nov;33(11):11925-11940. doi: 10.1096/fj.201801371R. Epub 2019 Aug 9. FASEB J. 2019. PMID: 31381863 Free PMC article.
Meprin beta is a membrane-bound metalloprotease involved in extracellular matrix assembly and inflammatory processes in health and disease. ...-Wichert, R., Scharfenberg, F., Colmorgen, C., Koudelka, T., Schwarz, J., Wetzel, S., Potempa, B., Potempa, J., Bartsch, J. W., Sa …
Meprin beta is a membrane-bound metalloprotease involved in extracellular matrix assembly and inflammatory processes in health and di …
Meprin β cleaves TREM2 and controls its phagocytic activity on macrophages.
Berner DK, Wessolowski L, Armbrust F, Schneppenheim J, Schlepckow K, Koudelka T, Scharfenberg F, Lucius R, Tholey A, Kleinberger G, Haass C, Arnold P, Becker-Pauly C. Berner DK, et al. Among authors: tholey a. FASEB J. 2020 May;34(5):6675-6687. doi: 10.1096/fj.201902183R. Epub 2020 Apr 1. FASEB J. 2020. PMID: 32237095
170 results